Reactome | ADCY7 [plasma membrane]

ADCY7 [plasma membrane]

Stable Identifier

R-MMU-379057

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

P51829

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - DAG and IP3 signaling (Mus musculus)
    - CaM pathway (Mus musculus)
      - Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Opioid Signalling (Mus musculus)
        
        G-protein mediated events (Mus musculus)
        
        Adenylate cyclase activating pathway (Mus musculus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        PLC beta mediated events (Mus musculus)
        
        Ca-dependent events (Mus musculus)
        
        CaM pathway (Mus musculus)
        
        Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
    - G alpha (z) signalling events (Mus musculus)
      - G alpha (z) inhibits adenylate cyclase (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)
- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'off' state (Mus musculus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Mus musculus)
        
        adenylate cyclases [plasma membrane] (Mus musculus)
        
        ADCY7 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P51829

Reference Genes

BioGPS Gene:11513

ENSEMBL:ENSMUSG00000031659

ENSEMBL:ENSMUSG00000031659.14

KEGG Gene (Mus musculus):11513

Monarch:11513

NCBI Gene:11513

UCSC:P51829

Reference Transcript

Other Identifiers

103392_at

10573747

11513

1420970_at

1450065_at

1456307_s_at

17503616

4306033

4322064

4329817

4376388

4440104

4458612

4544283

4546427

4563906

4564548

4600906

4614510

4717078

4750436

4795954

4796930

4847771

4853993

4943282

4992847

4996752

5077902

5080395

5136895

5203863

5208504

5214994

5244816

5299286

5336868

5379772

5419724

5421983

5451799

5459864

5471873

5520077

5550689

5591784

A_51_P441622

A_52_P586141

GE1571780

GO:0000166

GO:0002376

GO:0002819

GO:0003824

GO:0004016

GO:0005524

GO:0005886

GO:0006171

GO:0006954

GO:0007189

GO:0007193

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0022414

GO:0023052

GO:0035556

GO:0046872

GO:0055086

GO:0060135

GO:0071285

GO:0071361

GO:1900016

GO:1901135

ILMN_2688225

ILMN_3163572

U12919_s_at

aa177537_s_at

mMC020515

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Mus musculus)

as a member of

Adenylate cyclase [plasma membrane] (Mus musculus)

Inferred From

ADCY7 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001103226.1, NP_001032812.2, NP_031432.2, NP_001032813.1

IntEnz

4.6.1.1

Ensembl

ENSMUSP00000132528, ENSMUSP00000130594, ENSMUSP00000129252, ENSMUST00000098521, ENSMUST00000168545, ENSMUSG00000031659, ENSMUST00000171456, ENSMUST00000169037, ENSMUSP00000096122

PRO

P51829

MGI

102891

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