Reactome | Zwint [cytosol]

Zwint [cytosol]

Stable Identifier

R-MMU-376254

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ZWINT, Q9CQU5

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        KNL1:ZWINT [cytosol] (Mus musculus)
        
        Zwint [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQU5

Gene Names

Zwint

Reference Genes

BioGPS Gene:52696 Zwint

ENSEMBL:ENSMUSG00000019923

KEGG:mmu:52696 Zwint

Monarch:52696 Zwint

NCBI Gene:52696 Zwint

UCSC:Q9CQU5 Zwint

Reference Transcript

Other Identifiers

10363905

1423724_at

1427539_a_at

1427540_at

1429786_a_at

1429787_x_at

1460483_at

160455_s_at

163041_at

17234192

4320822

4424021

4513030

4575771

4839124

4963776

4974111

4987648

5016460

5171533

52696

5287512

5319139

5372859

5413282

5490473

5548773

5550992

5576375

99087_at

A_51_P163378

A_52_P495139

A_52_P509710

GE102529

GE121556

GO:0000070

GO:0000775

GO:0000776

GO:0005515

GO:0005634

GO:0005694

GO:0005829

GO:0007093

GO:0007094

GO:0016604

GO:0030425

GO:0031619

GO:0043226

GO:0051301

GO:0051649

GO:0180019

GO:1905325

ILMN_1228654

ILMN_2433482

mMC018227

Participates

as a component of

KNL1:ZWINT [cytosol] (Mus musculus)

Inferred From

ZWINT [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_079911.1, NP_001280613.1, NP_001280612.1

ENSEMBL

ENSMUST00000020081, ENSMUSP00000124429, ENSMUST00000160337, ENSMUST00000105431, ENSMUSG00000019923, ENSMUSP00000020081, ENSMUSP00000101071

PRO

Q9CQU5

MGI

1289227

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