Reactome | Cenpi [cytosol]

Cenpi [cytosol]

Stable Identifier

R-MMU-375293

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CENPI, Q8K1K4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K1K4

Gene Names

Cenpi

Reference Genes

BioGPS Gene:102920 Cenpi

ENSEMBL:ENSMUSG00000031262

KEGG:mmu:102920 Cenpi

Monarch:102920 Cenpi

NCBI Gene:102920 Cenpi

UCSC:Q8K1K4 Cenpi

Reference Transcript

Other Identifiers

102920

10601705

1436723_at

163479_at

17537648

4335488

4423817

4451144

4500328

4532852

4608046

4716427

4787494

4816857

4846016

4897379

4927406

4961706

4967481

4979934

5014383

5029400

5029846

5078916

5102014

5129857

5133773

5137189

5275001

5309391

5313178

5391796

5402603

5427059

5443059

5508447

A_51_P201035

A_55_P2064984

GE132596

GO:0000070

GO:0000775

GO:0000776

GO:0000939

GO:0003674

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0007059

GO:0008150

GO:0016604

GO:0034080

GO:0034508

GO:0043226

GO:0065003

ILMN_1244408

ILMN_2748499

ILMN_2821788

mMC023659

Participates

as a component of

CENP-(H,I, K) complex [cytosol] (Mus musculus)

Other forms of this molecule

Cenpi [nucleoplasm]

Inferred From

CENPI [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017173829.1, NP_001292560.1, NP_666036.1

ENSEMBL

ENSMUST00000101251, ENSMUSP00000098809, ENSMUST00000081064, ENSMUSG00000031262, ENSMUSP00000079851

PRO

Q8K1K4

MGI

2147897

Cite Us!