Reactome | Cenpi [cytosol]

Cenpi [cytosol]

Stable Identifier

R-MMU-375293

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CENPI, Q8K1K4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-(H,I, K) complex [cytosol] (Mus musculus)
        
        Cenpi [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K1K4

Gene Names

Cenpi

Reference Genes

BioGPS Gene:102920 Cenpi

ENSEMBL:ENSMUSG00000031262

ENSEMBL:ENSMUSG00000031262.13 Cenpi

KEGG Gene (Mus musculus):102920 Cenpi

Monarch:102920 Cenpi

NCBI Gene:102920 Cenpi

UCSC:Q8K1K4 Cenpi

Reference Transcript

Other Identifiers

102920

10601705

1436723_at

163479_at

17537648

4335488

4423817

4451144

4500328

4532852

4608046

4716427

4787494

4816857

4846016

4897379

4961706

4967481

5014383

5029400

5078916

5102014

5129857

5137189

5275001

5309391

5313178

5391796

5427059

5443059

A_51_P201035

A_55_P2064984

GE132596

GO:0000070

GO:0000278

GO:0000775

GO:0000776

GO:0000939

GO:0003674

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0007059

GO:0008150

GO:0016604

GO:0034080

GO:0034508

GO:0043226

GO:0065003

GO:0140014

ILMN_1244408

ILMN_2748499

ILMN_2821788

mMC023659

Participates

as a component of

CENP-(H,I, K) complex [cytosol] (Mus musculus)

Other forms of this molecule

Cenpi [nucleoplasm]

Inferred From

CENPI [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_666036.1, XP_017173830.1, NP_001292560.1, XP_017173829.1

Ensembl

ENSMUST00000081064, ENSMUSP00000079851, ENSMUSG00000031262, ENSMUSP00000098809, ENSMUST00000101251

PRO

Q8K1K4

MGI

2147897

Cite Us!