Reactome | Sstr4 [plasma membrane]

Sstr4 [plasma membrane]

Stable Identifier

R-MMU-374745

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

SSTR4, P49660

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Peptide ligand-binding receptors (Mus musculus)
        
        Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)
        
        Somatostatin receptors [plasma membrane] (Mus musculus)
        
        Sstr4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P49660

Gene Names

Sstr4

Reference Genes

BioGPS Gene:20608 Sstr4

ENSEMBL:ENSMUSG00000037014

KEGG:mmu:20608 Sstr4

Monarch:20608 Sstr4

NCBI Gene:20608 Sstr4

UCSC:P49660 Sstr4

Reference Transcript

RefSeq:NM_009219.3 Sstr4

Participates

as a member of

Somatostatin receptors [plasma membrane] (Mus musculus)

Inferred From

SSTR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_033245.2

ZINC - Substances

SSR4_MOUSE

ZINC target

P49660

PRO

P49660

GlyGen

P49660

MGI

105372

ZINC - Predictions - Purchasable

SSR4_MOUSE

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.544	3