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Crk [cytosol]
Stable Identifier
R-MMU-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CRK, Q64010
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Regulation of signaling by CBL (Mus musculus)
CBL binds CRK (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:CRK [cytosol] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
CBL:CRKL binds RAPGEF1 (Mus musculus)
p(Y700,731,774)-CBL:CRK [cytosol] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Mus musculus)
p(Y700,731,774)-CBL:CRK [cytosol] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
Activation of RAC1 by the PXN:CRK complex (Mus musculus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Phosphorylated PXN recruits the CRK complex (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by MET (Mus musculus)
MET promotes cell motility (Mus musculus)
MET activates RAP1 and RAC1 (Mus musculus)
CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
DOCK7 activates RAC1 (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
GAB1 recruits CRK,CRKL to MET (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
RAPGEF1 activates RAP1 (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
RAPGEF1 binds CRK,CRKL (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
MET receptor recycling (Mus musculus)
GGA3 associates with activated MET receptor (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
ARMS-mediated activation (Mus musculus)
ARMS is phosphorylated by active TrkA receptor (Mus musculus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Mus musculus)
ARMS:Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Phospho-ARMS:Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
C3G stimulates nucleotide exchange on Rap1 (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Phospho-ARMS:Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Crk's SH3 domain engages C3G (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Phospho-ARMS:Crk [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
Crk binds to the active PDGF receptor (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
p130Cas and C3G bind PDGFR bound Crk (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Mus musculus)
CRK, CRKL [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
CRK binds BCAR1 and or PXN (Mus musculus)
Crk [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
Crk [cytosol] (Mus musculus)
DOCK180:ELMO binds CRK (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
Crk [cytosol] (Mus musculus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Crk [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q64010
Gene Names
Crk
Reference Genes
BioGPS Gene:12928 Crk
ENSEMBL:ENSMUSG00000017776
ENSEMBL:ENSMUSG00000017776.16 Crk
KEGG Gene (Mus musculus):12928 Crk
Monarch:12928 Crk
NCBI Gene:12928 Crk
UCSC:Q64010 Crk
Reference Transcript
RefSeq:NM_133656.5 Crk
Other Identifiers
10378732
12928
1416201_at
1425855_a_at
1448248_at
1460176_at
17253096
4491678
4522149
4571781
4760658
5032134
5329742
5461381
5539474
5544506
94065_at
A_51_P180452
A_52_P515840
A_52_P618807
A_55_P2173014
A_55_P2500388
GE33047
GO:0001764
GO:0001784
GO:0001878
GO:0002376
GO:0002685
GO:0005159
GO:0005515
GO:0005737
GO:0005856
GO:0005886
GO:0006629
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007167
GO:0008092
GO:0008283
GO:0008360
GO:0009966
GO:0014911
GO:0015629
GO:0016020
GO:0016358
GO:0016477
GO:0017124
GO:0019899
GO:0019900
GO:0019904
GO:0021766
GO:0021987
GO:0023052
GO:0030010
GO:0030036
GO:0030154
GO:0030159
GO:0030307
GO:0030674
GO:0030971
GO:0031594
GO:0031625
GO:0032956
GO:0032991
GO:0033628
GO:0034330
GO:0035020
GO:0035022
GO:0035591
GO:0035685
GO:0035728
GO:0038026
GO:0042060
GO:0042169
GO:0042542
GO:0043087
GO:0043226
GO:0043621
GO:0045309
GO:0045953
GO:0046330
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0050773
GO:0060090
GO:0060326
GO:0061024
GO:0061045
GO:0061847
GO:0071560
GO:0071732
GO:0072657
GO:0097110
GO:0098542
GO:0098698
GO:0098749
GO:1900026
GO:1901652
GO:1902531
GO:1904395
GO:1990090
GO:1990314
GO:1990782
GO:1990859
GO:2000145
GO:2000146
GO:2000404
ILMN_1221405
ILMN_2418682
ILMN_2652663
ILMN_2684889
ILMN_2987844
mMC001843
mMR029825
Participates
as an input of
Crk binding to p130cas (Mus musculus)
CRK binds BCAR1 and or PXN (Mus musculus)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Phospho-ARMS:Crk [cytosol] (Mus musculus)
ARMS:Crk [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
as a member of
CRK, CRKL [cytosol] (Mus musculus)
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_598417.2
Ensembl
ENSMUST00000017920
,
ENSMUSP00000017920
,
ENSMUSG00000017776
PRO
Q64010
MGI
88508
PDB
5JN0
,
1JU5
,
2GGR
,
1M3A
,
1M3C
,
1CKB
,
1B07
,
1M30
,
1CKA
,
5L23
,
1M3B
,
5IH2
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.462
3
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