RasGRP interacts with DAG and Ca2+

Stable Identifier
R-MMU-2730865
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RasGRP interacts with DAG and Ca2+
Ras guanyl nucleotide-releasing proteins (RasGRPs) are guanyl nucleotide exchange factors (GEFs) that activate Ras ultimately leading to MAPK activation. RasGRPs have a catalytic domain composed of Ras exchange motif (REM) and a CDC25 domain, an atypical pair of EF hands that bind calcium and a DAG-binding C1 domain. After PIP2 hydrolysis, RasGRPs are recruited to the plasma membrane by binding to DAG and calcium (Stone 2011, Liu et al. 2007). Upon T-cell activation RasGRP1 specifically interacts with and activates Ras on Golgi instead of the plasma membrane (Bivona et al. 2003). It remains to be determined whether activation of N-Ras by RasGRP1 in mast cells occurs in the Golgi or the plasma membrane (Liu et al. 2007). RasGRP4 is mast cell specific and is involved in the controls Ras activation.
Literature References
PubMed ID Title Journal Year
22262848 The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development

Zhu, M, Fuller, DM, Zhang, W

J. Biol. Chem. 2012
17190838 An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response

Liu, Y, Zhu, M, Nishida, K, Hirano, T, Zhang, W

J. Exp. Med. 2007
21779502 Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells

Stone, JC

Genes Cancer 2011
Participants
Input
Output
Orthologous Events
RasGRP interacts with DAG and Ca2+ (Homo sapiens)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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