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HSPA8 [cytosol]
Stable Identifier
R-MMU-264476
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P63017
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)
HSP70s:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
HSP70s:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Hikeshi binds HSP70s:ATP (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Hikeshi:HSP70s:ATP [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)
Hikeshi:HSP70s:ATP [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
ATP binding to HSP90 triggers conformation change (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
ATP hydrolysis by HSP70 (Mus musculus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP70 binds to HSP40:nascent protein (Mus musculus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
PKR-mediated signaling (Mus musculus)
FA core complex:HSP70s binds PKR (Mus musculus)
FA Core Complex:HSP70s [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Mus musculus)
FA Core Complex:HSP70s [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Mus musculus)
AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
AUF1 binds translation and heat shock proteins (Mus musculus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
clathrin:HSPA8:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
trans-Golgi Network Vesicle Budding (Mus musculus)
Golgi Associated Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)
HSC70:Auxillin Complex [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
Lysosome Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)
HSC70:Auxillin Complex [cytosol] (Mus musculus)
HSPA8 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P63017 Hspa8
Gene Names
Hspa8, Hsc70, Hsc73
Chain
initiator methionine:, chain:2-646
Reference Genes
BioGPS Gene:15481 Hspa8
ENSEMBL:ENSMUSG00000015656.18 Hspa8
KEGG Gene (Mus musculus):15481 Hspa8
Monarch:15481 Hspa8
NCBI Gene:15481 Hspa8
UCSC:P63017 Hspa8
Reference Transcript
RefSeq:NM_031165.4 Hspa8
Other Identifiers
10368025
10528021
10584572
1420622_a_at
1420623_x_at
1455789_x_at
15481
17516365
4319466
4375983
4551525
4631211
4725668
4763740
4773098
4856253
4870419
4872942
4875329
4957859
4960695
4980268
5013139
5070125
5146835
5175250
5214873
5256594
5388514
5429764
5526135
96564_at
A_51_P170371
A_52_P12877
A_55_P2080603
A_55_P2909278
A_55_P2910890
A_66_P137434
GO:0000082
GO:0000166
GO:0000278
GO:0000398
GO:0000974
GO:0001664
GO:0001786
GO:0001822
GO:0001916
GO:0001917
GO:0002376
GO:0003723
GO:0003824
GO:0005102
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005681
GO:0005730
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005829
GO:0005856
GO:0005874
GO:0005882
GO:0005886
GO:0006351
GO:0006355
GO:0006397
GO:0006457
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007018
GO:0007040
GO:0007519
GO:0008021
GO:0008088
GO:0008289
GO:0008380
GO:0009410
GO:0009986
GO:0010045
GO:0010628
GO:0010667
GO:0012501
GO:0014069
GO:0014823
GO:0016020
GO:0016071
GO:0016191
GO:0016192
GO:0016787
GO:0016887
GO:0019899
GO:0021549
GO:0022414
GO:0030163
GO:0030424
GO:0030425
GO:0030674
GO:0030900
GO:0031072
GO:0031410
GO:0031625
GO:0031647
GO:0031686
GO:0031906
GO:0032279
GO:0032355
GO:0032570
GO:0032984
GO:0032991
GO:0034330
GO:0034605
GO:0042026
GO:0042277
GO:0042470
GO:0042594
GO:0043025
GO:0043195
GO:0043197
GO:0043198
GO:0043204
GO:0043209
GO:0043226
GO:0043531
GO:0044183
GO:0044309
GO:0044743
GO:0044788
GO:0044829
GO:0044849
GO:0045471
GO:0045862
GO:0045892
GO:0046034
GO:0048026
GO:0048471
GO:0048856
GO:0050766
GO:0051082
GO:0051085
GO:0051087
GO:0051726
GO:0055085
GO:0055086
GO:0055131
GO:0060090
GO:0061024
GO:0061077
GO:0061635
GO:0061684
GO:0061738
GO:0061740
GO:0065003
GO:0070062
GO:0070301
GO:0071276
GO:0072318
GO:0097214
GO:0098684
GO:0098690
GO:0098793
GO:0098794
GO:0098880
GO:0098978
GO:0099175
GO:0099523
GO:0099524
GO:0099634
GO:0101031
GO:0140545
GO:0140657
GO:0140662
GO:1900226
GO:1901135
GO:1902904
GO:1904592
GO:1904593
GO:1904764
GO:1990124
GO:1990832
GO:1990833
GO:1990834
GO:1990836
GO:1990904
ILMN_1246458
ILMN_1249586
ILMN_2772022
ILMN_2918479
Msa.23647.0_f_at
Msa.34101.0_f_at
Msa.778.0_f_at
mMC025232
u73744_f_at
Participates
as a component of
HSC70:Auxillin Complex [cytosol] (Mus musculus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
as an input of
AUF1 binds translation and heat shock proteins (Mus musculus)
as a member of
HSP70 proteins [cytosol] (Mus musculus)
Other forms of this molecule
Me3K561-HSPA8 [nucleoplasm]
HSPA8 [secretory granule lumen]
HSPA8 [extracellular region]
HSPA8 [ficolin-1-rich granule lumen]
HSPA8 [nucleoplasm]
HSPA8 [plasma membrane]
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Hspa8 [late endosome lumen]
Hspa8 [cytosol]
Inferred From
HSPA8 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_112442.2
Ensembl
ENSMUST00000015800
,
ENSMUSP00000015800
,
ENSMUSG00000015656
PRO
P63017
MGI
105384
HMDB Protein
HMDBP13802
PDB
3CQX
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O41974 O41974
0.576
3
UniProt:Q08460 Kcnma1
2
Kcnma1 [plasma membrane]
(R-MMU-9667781)
KCNMA1 [plasma membrane]
(R-MMU-418462)
0.527
2
UniProt:P43883 Plin2
3
p-Plin2 [cytosol]
(R-MMU-9613673)
p-Plin2 [lipid droplet]
(R-MMU-9613540)
Plin2 [lipid droplet]
(R-MMU-9613518)
0.524
3
UniProt:O88447
1
Klc1 [cytosol]
(R-MMU-983284)
0.499
3
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