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active caspase-8 [cytosol]
Stable Identifier
R-MMU-2562550
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
CLEC7A/inflammasome pathway (Mus musculus)
ASC binds Caspase-8 complex (Mus musculus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 binds MALT (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 cleaves IL1B precursor (Mus musculus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
TRIF-mediated programmed cell death (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Apoptotic execution phase (Mus musculus)
Apoptotic cleavage of cellular proteins (Mus musculus)
Caspase-mediated cleavage of cytoskeletal proteins (Mus musculus)
Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-mediated cleavage of plectin-1 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation, myristolyation of BID and translocation to mitochondria (Mus musculus)
Caspase-8 activates BID by cleavage (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
RIPK3 is cleaved by CASP8 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
TRAF1 is cleaved by caspases (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Caspase-8 dimer [cytosol]
(Mus musculus)
Participates
as an input of
Caspase-8 binds MALT (Mus musculus)
Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)
as a component of
MALT1:active caspase-8 [cytosol] (Mus musculus)
as an output of
Caspase-8 processing within TLR4 complex (Mus musculus)
This entity regulates
Negatively
N4BP1 binds IKBKG
(Mus musculus)
Inferred From
active caspase-8 [cytosol]
(Homo sapiens)
active caspase-8 [cytosol]
(Homo sapiens)
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