Ntn4 binds laminin-gamma-1 and -3

Stable Identifier
R-MMU-2447193
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, extracellular region
Synonyms
Netrin-4 binds laminin-gamma-1 and -3
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ntn4 binds laminin-gamma-1 and -3
Netrins are a family of extracellular proteins that include axonal guidance factors. Their N-terminal domains are homologous to the LN domains of laminins. Netrin-4 (but not other forms) can bind laminin gamma-1 and gamma-3 short arms in basement membrane, suggesting a role in regulating basement membrane formation (Schneiders et al. 2007). Netrin-4 has been found associated in a functional complex with laminin gamma-1 chain and integrin alpha6beta1, suggesting a role in regulation of neurogenesis in the olfactory system (Staquicini et al. 2009).
Literature References
PubMed ID Title Journal Year
17588941 Binding of netrin-4 to laminin short arms regulates basement membrane assembly

Schneiders, FI, Maertens, B, Böse, K, Li, Y, Brunken, WJ, Paulsson, M, Smyth, N, Koch, M

J. Biol. Chem. 2007
Participants
Input
Output
Orthologous Events
NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)
Authored
Jupe, S  (2012-07-31)
Reviewed
Ricard-Blum, S  (2013-05-22)
Created
Jupe, S  (2012-08-13)
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