Reactome | Adam10 cleaves Notch2

Adam10 cleaves Notch2

Stable Identifier

R-MMU-2193065

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Adam10 knockout mice have impaired development of the marginal zone B-cell lineage, known to be dependent on Notch2 signaling. Notch2 activation is also impaired in Adam10 knockout mice, supporting the role of Adam10 in Notch2 proteolytic processing and activation upon ligand binding (Gibb et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20156974	ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo Gibb, DR, El Shikh, M, Kang, DJ, Rowe, WJ, El Sayed, R, Cichy, J, Yagita, H, Tew, JG, Dempsey, PJ, Crawford, HC, Conrad, DH	J Exp Med	2010