Reactome | Col8a1 [extracellular region]

Col8a1 [extracellular region]

Stable Identifier

R-MMU-2192736

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL8A1(28-744), Q00780

Locations in the PathwayBrowser

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Extracellular matrix organization (Mus musculus)

- Collagen formation (Mus musculus)
  - Assembly of collagen fibrils and other multimeric structures (Mus musculus)
    - Formation of collagen networks (Mus musculus)
      - Collagen networks [extracellular region] (Mus musculus)
        
        Collagen type VIII fibril [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)
      - Network forming tropocollagens [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)
  - Collagen biosynthesis and modifying enzymes (Mus musculus)
    - Secretion of collagens (Mus musculus)
      - Collagens and tropocollagens [extracellular region] (Mus musculus)
        
        Non-fibrillar collagens [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)
- Degradation of the extracellular matrix (Mus musculus)
  - Collagen degradation (Mus musculus)
    - Collagen type VIII degradation by MMP1 (Mus musculus)
      - Collagen type VIII fibril [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)
- Integrin cell surface interactions (Mus musculus)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Mus musculus)
      - Collagen type VIII fibril [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Mus musculus)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Mus musculus)
        
        Collagen type VIII fibril [extracellular region] (Mus musculus)
        
        Tropocollagen type VIII [extracellular region] (Mus musculus)
        
        Col8a1 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:Q00780

Gene Names

Col8a1

Reference Genes

BioGPS Gene:12837 Col8a1

ENSEMBL:ENSMUSG00000068196

KEGG:mmu:12837 Col8a1

Monarch:12837 Col8a1

NCBI Gene:12837 Col8a1

UCSC:Q00780 Col8a1

Reference Transcript

RefSeq:NM_007739.2 Col8a1

Other Identifiers

100308_at

10440091

12837

1418440_at

1418441_at

1455627_at

17331162

4476988

4570390

4652693

4661762

4706520

4752693

4764362

4788459

4804938

4809008

4863995

4958851

5041311

5157493

5172259

5196078

5198847

5281420

5294470

5330353

5394259

5400882

5476507

5502059

5555810

A_52_P184855

A_52_P282058

A_52_P292792

GE34870

GO:0001525

GO:0001935

GO:0005198

GO:0005515

GO:0005576

GO:0005581

GO:0005604

GO:0005615

GO:0007155

GO:0010811

GO:0030020

GO:0030154

GO:0030312

GO:0031012

GO:0035987

GO:0048593

ILMN_1226426

ILMN_2503553

Msa.2740.0_at

mMC012271

mMC024115

Participates

as a component of

Tropocollagen type VIII [extracellular region] (Mus musculus)

Other forms of this molecule

Col8a1 [endoplasmic reticulum lumen]

Col8a1 [extracellular region]

Col8a1 [endoplasmic reticulum lumen]

Inferred From

Collagen alpha-1(VIII) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_031765.2

ENSEMBL

ENSMUSP00000086745, ENSMUST00000089332, ENSMUSG00000068196

PRO

Q00780

MGI

88463

PDB

1O91