Reactome | phospho-Wasf2 [cytosol]

phospho-Wasf2 [cytosol]

Stable Identifier

R-MMU-2130179

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y150,S343,T346-WASF2, Q8BH43

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
      - Detachment of WASP/WAVE (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
      - p-ERK phosphorylates WAVEs and ABI (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate WASPs and WAVEs (Mus musculus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        Detachment of WASP/WAVE (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)
        
        p-ERK phosphorylates WAVEs and ABI (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        p-Y,S,T-WAVE [cytosol] (Mus musculus)
        
        phospho-Wasf2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BH43

Gene Names

Wasf2

Reference Genes

BioGPS Gene:242687 Wasf2

ENSEMBL:ENSMUSG00000028868

ENSEMBL:ENSMUSG00000028868.14 Wasf2

KEGG Gene (Mus musculus):242687 Wasf2

Monarch:242687 Wasf2

NCBI Gene:242687 Wasf2

UCSC:Q8BH43 Wasf2

Reference Transcript

Other Identifiers

10508805

1438683_at

1454673_at

17419524

242687

4323289

4331443

4495931

4570043

4616757

4901119

5005336

5025439

5155163

5193883

5260104

5348799

5358739

5394429

5421592

5510320

5555642

5603835

A_51_P399373

A_52_P581440

A_52_P597860

A_55_P1978661

A_55_P2740163

GE136819

GO:0001525

GO:0001667

GO:0001726

GO:0003779

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005856

GO:0005886

GO:0005911

GO:0006897

GO:0007010

GO:0008092

GO:0010592

GO:0016020

GO:0016192

GO:0016323

GO:0016601

GO:0017124

GO:0023052

GO:0030027

GO:0030032

GO:0030036

GO:0030048

GO:0030154

GO:0031209

GO:0031410

GO:0032991

GO:0034237

GO:0034330

GO:0035855

GO:0042995

GO:0043226

GO:0045202

GO:0048856

GO:0048870

GO:0051018

GO:0051497

GO:0071933

GO:0072673

GO:0098974

GO:0099173

GO:2000601

ILMN_1235619

ILMN_2495363

mMC013409

mMR030946

Participates

as a member of

p-Y,S,T-WAVE [cytosol] (Mus musculus)

Other forms of this molecule

Wasf2 [cytosol]

phospho-Wasf2 [cytosol]

Inferred From

p-Y150,S343,T346-WASF2 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 343 (in Homo sapiens)

Coordinate

343

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 346 (in Homo sapiens)

Coordinate

346

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 150 (in Homo sapiens)

Coordinate

150

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_700472.1, XP_006538911.1, XP_006538912.1, XP_006538913.1

Ensembl

ENSMUST00000084241, ENSMUSP00000101532, ENSMUST00000105912, ENSMUSG00000028868, ENSMUSP00000081263

PRO

Q8BH43

MGI

1098641

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