Trans-phosphorylation of Tie2

Stable Identifier
R-MMU-211119
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trans-phosphorylation of Tie2
The dimerization of Tie2 leads to autophosphorylation and activation of its kinase domain. There are multiple tyrosine phosphorylation sites in the Tie2 kinase domain. The phosphorylated tyrosine residues provide the interaction site for the SH2 domains of other downstream signaling molecules like PI3K, Grb2, SHP2 etc.
Literature References
PubMed ID Title Journal Year
14749497 Functional significance of Tie2 signaling in the adult vasculature

Peters, KG, Kontos, CD, Lin, PC, Wong, AL, Rao, P, Huang, L, Dewhirst, MW, Sankar, S

Recent Prog Horm Res 2004
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Tie2/Ang1 dimer [plasma membrane]

Physical Entity
Tie2/Ang1 dimer [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Trans-phosphorylation of Tie2 (Homo sapiens)
Authored
Garapati, P V  (2008-03-05)
de Bono, B  (2008-03-05)
Created
Garapati, P V  (2008-01-28)
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