The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm

Stable Identifier
R-MMU-209285
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm
Based on studies of presenilin-1 (Psen1) deficient mouse embryos and the effect of gamma-secretase inhibitors, gamma-secretase complex containing Psen1 is responsible for the cleavage of mouse Notch1 at S3 and release of the NICD1.
Literature References
PubMed ID Title Journal Year
9620803 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, EH, Kisslinger, JA, Kopan, R

Nature 1998
10206645 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B, Annaert, W, Cupers, P, Saftig, P, Craessaerts, K, Mumm, JS, Schroeter, EH, Schrijvers, V, Wolfe, MS, Ray, WJ, Goate, A, Kopan, R

Nature 1999
Participants
Input
Output
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase [plasma membrane]

Physical Entity
gamma-secretase [plasma membrane] (Mus musculus)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
NEXT1 is cleaved to produce NICD1 (Homo sapiens)
Authored
Williams, MG  (2006-09-21)
Reviewed
Haw, R  (2012-02-06)
Created
Williams, MG  (2006-09-21)
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