Reactome | SEC24A [endoplasmic reticulum membrane]

SEC24A [endoplasmic reticulum membrane]

Stable Identifier

R-MMU-203992

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

endoplasmic reticulum membrane

Synonyms

Q3U2P1

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Mus musculus)
      - Budding of COPII coated vesicle (Mus musculus)
        
        COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Coat Assembly (Mus musculus)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)
        
        COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Formation of COPII vesicle (Mus musculus)
      - COPII [endoplasmic reticulum membrane] (Mus musculus)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII [endoplasmic reticulum membrane] (Mus musculus)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
    - Fusion of COPII vesicle with Golgi complex (Mus musculus)
      - COPII [endoplasmic reticulum membrane] (Mus musculus)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII [endoplasmic reticulum membrane] (Mus musculus)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        Loss of SAR1B GTPase (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC31:SEC13 and v-SNARE recruitment (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        Cargo concentration in the ER (Mus musculus)
        
        Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Loss of SAR1B GTPase (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - SEC31:SEC13 and v-SNARE recruitment (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)
    - Cargo concentration in the ER (Mus musculus)
      - Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC24A [endoplasmic reticulum membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3U2P1

Reference Genes

BioGPS Gene:77371

ENSEMBL:ENSMUSG00000036391

ENSEMBL:ENSMUSG00000036391.17

KEGG Gene (Mus musculus):77371

Monarch:77371

NCBI Gene:77371

UCSC:Q3U2P1

Reference Transcript

Other Identifiers

10385719

114800_at

1433934_at

17262521

4319212

4351311

4357153

4370036

4469175

4494570

4551707

4562859

4584494

4589226

4598913

4631452

4642490

4655969

4680294

4713662

4872566

4884607

4892402

4970032

5009954

5019413

5093494

5104741

5126832

5196319

5239680

5267930

5333656

5348485

5349087

5360949

5373683

5515631

5558370

5567951

5611283

77371

A_52_P409711

A_52_P6451

A_66_P117506

GE1551918

GO:0000149

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0031410

GO:0032374

GO:0042632

GO:0043226

GO:0046872

GO:0050714

GO:0061024

GO:0070971

GO:0090110

ILMN_1244794

ILMN_2664764

mMC017539

mMR030023

Participates

as a member of

SEC24 [endoplasmic reticulum membrane] (Mus musculus)

Other forms of this molecule

phospho-p-SEC24A [cytosol]

SEC24A [ER to Golgi transport vesicle membrane]

SEC24A [cytosol]

Inferred From

SEC24A [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

NP_780464.2, NP_001277714.1

Ensembl

ENSMUST00000064297, ENSMUSP00000068065, ENSMUSP00000104725, ENSMUST00000109097, ENSMUSG00000036391

PRO

Q3U2P1

MGI

1924621

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