Reactome | PRKAG2 [cytosol]

PRKAG2 [cytosol]

Stable Identifier

R-MMU-200419

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q91WG5

Locations in the PathwayBrowser

Expand all

Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - Thr-180 of ULK1 is phosphorylated (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - ULK complex translocates to the ER (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - ULK1 phosphorylates Beclin-1 (Mus musculus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - p-AMPK:AMP binds the ULK complex (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Mus musculus)
      - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
    - p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
      - p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        SESN1,2,3 bind AMPK (Mus musculus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Mus musculus)
        
        p-AMPK heterotrimer [cytosol] (Mus musculus)
        
        AMPK gamma [cytosol] (Mus musculus)
        
        PRKAG2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91WG5 Prkag2

Gene Names

Prkag2

Chain

chain:1-566

Reference Genes

BioGPS Gene:108099 Prkag2

KEGG:mmu:108099 Prkag2

Monarch:108099 Prkag2

NCBI Gene:108099 Prkag2

UCSC:Q91WG5 Prkag2

Reference Transcript

Other Identifiers

10528702

108099

110833_at

1423831_at

1423832_at

1431263_at

1451140_s_at

162629_at

168023_at

17446322

4320983

4337124

4388211

4455021

4498257

4536220

4657513

4664151

4743079

4760809

4837870

4851619

4970788

5005264

5061127

5072181

5090967

5135481

5191649

5205717

5211981

5214282

5239683

5254173

5318133

5338983

5366623

5417137

5457934

5476651

5479765

5591733

5594417

A_51_P460869

A_52_P389105

A_55_P2013296

A_55_P2715316

GE131105

GO:0000166

GO:0003824

GO:0004679

GO:0004862

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005977

GO:0006110

GO:0006629

GO:0006631

GO:0006633

GO:0008603

GO:0008607

GO:0016208

GO:0016740

GO:0019217

GO:0019887

GO:0019901

GO:0030295

GO:0031588

GO:0031669

GO:0035556

GO:0042149

GO:0043531

GO:0043609

GO:0045722

GO:0098772

GO:0140096

ILMN_1255882

ILMN_3161626

Msa.31227.0_s_at

mMC006289

Participates

as a component of

AMPK heterotrimer (active) [cytosol] (Mus musculus)

as a member of

AMPK gamma [cytosol] (Mus musculus)

Other forms of this molecule

Prkag2 [nucleoplasm]

PRKAG2 [endoplasmic reticulum lumen]

PRKAG2 [nucleoplasm]

Prkag2 [cytosol]

Inferred From

PRKAG2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_663376.2, NP_001164027.1

ENSEMBL

ENSMUST00000030784, ENSMUSP00000030784, ENSMUST00000114975, ENSMUSG00000028944, ENSMUSP00000110626

PRO

Q91WG5

MGI

1336153

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