Reactome | H2-Ea [plasma membrane]

H2-Ea [plasma membrane]

Stable Identifier

R-MMU-197588

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

HLA class II histocompatibility antigen, DR alpha chain precursor, P01904

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - LAG3 (CD233) binds MHC II (Mus musculus)
      - LAG3:MHC II [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Recruitment of clathrin coated vesicle by Ii (Mus musculus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-inhibition by PD-1 (Mus musculus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - Change of PKC theta conformation (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Generation of second messenger molecules (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Phosphorylation of SLP-76 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Phosphorylation of TBSMs in LAT (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
      - Activation of Lck (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Inactivation of LCK by PTPN22 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Inactivation of Lck by Csk (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
    - Translocation of ZAP-70 to Immunological synapse (Mus musculus)
      - Activation of ZAP-70 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - PTPN22 dephosphorylates ZAP70 (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Phosphorylation of ZAP-70 by Lck (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II alpha/beta dimer [plasma membrane] (Mus musculus)
        
        HLA II alpha chain [plasma membrane] (Mus musculus)
        
        H2-Ea [plasma membrane] (Mus musculus)