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About
What is Reactome ?
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PP2A [cytosol]
Stable Identifier
R-MMU-196206
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
Mitotic Spindle Checkpoint (Mus musculus)
Amplification of signal from the kinetochores (Mus musculus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Mad1 binds kinetochore (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Release of activated MAD2 from kinetochores (Mus musculus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Mad1:kinetochore complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Separation of Sister Chromatids (Mus musculus)
ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Separation of sister chromatids (Mus musculus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Mitotic Prometaphase (Mus musculus)
EML4 and NUDC in mitotic spindle formation (Mus musculus)
EML4 recruits NUDC to mitotic spindle (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore capture of astral microtubules (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Resolution of Sister Chromatid Cohesion (Mus musculus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore assembly (Mus musculus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet homeostasis (Mus musculus)
Platelet sensitization by LDL (Mus musculus)
PECAM-1 binds PP2A (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-PECAM:PP2A [plasma membrane] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CTLA4 inhibitory signaling (Mus musculus)
CTLA-4 binds B7-1/B7-2 (Mus musculus)
CTLA4 dimer:PP2A [plasma membrane] (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Mus musculus)
CTLA4 dimer:PP2A [plasma membrane] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Dephosphorylation of AKT by PP2A (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A binds CTLA4 dimer (Mus musculus)
CTLA4 dimer:PP2A [plasma membrane] (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of CTLA-4 (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Mus musculus)
CTLA4 dimer:PP2A [plasma membrane] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)
PP2A [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
PP2A dephosphorylates RAF1 (Mus musculus)
PP2A [cytosol] (Mus musculus)
RAF activation (Mus musculus)
PP2A dephosphorylates KSR1 (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A dephosphorylates inactive RAFs (Mus musculus)
PP2A [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate Formins (Mus musculus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Microtubule-bound kinetochore [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Signaling by WNT (Mus musculus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
AXIN is phosphorylated in the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Assembly of the destruction complex (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Association of beta-catenin with the destruction complex (Mus musculus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Beta-catenin phosphorylation cascade (Mus musculus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Mus musculus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
Phosphorylation of APC component of the destruction complex (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Mus musculus)
Beta-catenin is released from the destruction complex (Mus musculus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
PP2A [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PP2A regulatory subunit B56 [cytosol]
(Mus musculus)
PP2A-catalytic subunit C [cytosol]
(Mus musculus)
PP2A-subunit A [cytosol]
(Mus musculus)
Participates
as an input of
PECAM-1 binds PP2A (Mus musculus)
PP2A binds CTLA4 dimer (Mus musculus)
Assembly of the destruction complex (Mus musculus)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)
as a component of
p-PECAM:PP2A [plasma membrane] (Mus musculus)
CTLA4 dimer:PP2A [plasma membrane] (Mus musculus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Mus musculus)
Kinetochore [cytosol] (Mus musculus)
as an output of
Phosphorylation of CTLA-4 (Mus musculus)
Beta-catenin is released from the destruction complex (Mus musculus)
Inferred From
PP2A [cytosol]
(Homo sapiens)
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