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Vav2 [cytosol]
Stable Identifier
R-MMU-195012
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
VAV2, Q60992
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPH-ephrin mediated repulsion of cells (Mus musculus)
SFKs phosphorylate VAV2,3 (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-EPHs bind VAV2,3 (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
VAV family:PIP2 [plasma membrane] (Mus musculus)
VAV family [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-SLP-76 binds VAV (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-SLP-76:VAV [cytosol] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Phosphorylation of BTK by p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-SYK/p-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Release of p-PLCG1 (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Autophosphorylation of BTK/ITK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Phosphorylation of TEC kinases by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Phosphorylation and activation of VAV (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Recruitment of VAV to p-SLP-76 (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Phosphorylation of VAV (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
Src kinases phosphorylate VAV (Mus musculus)
PIP3:VAV1,2,3 [plasma membrane] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
VAV family [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
CDC42 GTPase cycle (Mus musculus)
CDC42 GEFs activate CDC42 (Mus musculus)
CDC42 GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 GEFs activate RAC2 (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RAC3 GTPase cycle (Mus musculus)
RAC3 GEFs activate RAC3 (Mus musculus)
RAC3 GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RHOA GTPase cycle (Mus musculus)
RHOA GEFs activate RHOA (Mus musculus)
RHOA GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RHOB GTPase cycle (Mus musculus)
RHOB GEFs activate RHOB (Mus musculus)
RHOB GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RHOC GTPase cycle (Mus musculus)
RHOC GEFs activate RHOC (Mus musculus)
RHOC GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
RHOG GTPase cycle (Mus musculus)
RHOG GEFs activate RHOG (Mus musculus)
RHOG GEFs [cytosol] (Mus musculus)
Vav2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60992 Vav2
Gene Names
Vav2
Chain
chain:1-868
Reference Genes
BioGPS Gene:22325 Vav2
KEGG:mmu:22325 Vav2
Monarch:22325 Vav2
NCBI Gene:22325 Vav2
UCSC:Q60992 Vav2
Reference Transcript
RefSeq:NM_009500.2 Vav2
Other Identifiers
10481210
1421272_at
1435244_at
17383284
22325
4313450
4347934
4374396
4483366
4562685
4666443
4680380
4692020
4705980
4748898
4751490
4796285
4802131
4826593
4905417
4964027
4972327
4987804
5014471
5050384
5073537
5130553
5173844
5212027
5318001
5346803
5355075
5385701
5419191
5421472
5524566
5529833
5584488
5603705
5609664
5614055
5614096
92998_at
A_51_P467591
A_52_P625296
A_55_P2034979
A_55_P2717104
GE134281
GE33883
GO:0001525
GO:0001784
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007264
GO:0008361
GO:0016477
GO:0030031
GO:0030032
GO:0035556
GO:0046872
GO:0048870
GO:0051897
GO:0098772
ILMN_1223067
ILMN_1225994
ILMN_2436992
U37017_s_at
mMC000959
mMR026395
Participates
as a member of
RHOA GEFs [cytosol] (Mus musculus)
RHOC GEFs [cytosol] (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
RHOB GEFs [cytosol] (Mus musculus)
RAC3 GEFs [cytosol] (Mus musculus)
VAV2,VAV3 [cytosol] (Mus musculus)
GEFs [cytosol] (Mus musculus)
VAV family [cytosol] (Mus musculus)
VAV1,2,3 [cytosol] (Mus musculus)
as a candidate of
CDC42 GEFs [cytosol] (Mus musculus)
RHOG GEFs [cytosol] (Mus musculus)
Other forms of this molecule
Vav2 [cytosol]
phospho-Vav2 [cytosol]
Inferred From
VAV2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033526.1
ENSEMBL
ENSMUST00000056176
,
ENSMUSP00000062782
PRO
Q60992
MGI
102718
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