HNF1a transactivates Pklr

Stable Identifier
R-MMU-186509
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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HNF1a transactivates Pklr

Hnf1a (Tcf1) has been shown to activate the Liver-type pyruvate kinase (pklr) gene in rat INS1 cells (Wang et al. 1999). It has been shown to bind the Pklr gene in mouse islets by chromatin immunoprecipitation, and decreased expression is observed in Hnf1a-/- islets (Parrizas et al, 2001). Plkr expression in the developing pancreas in vivo is lost by embryonic day 18.5 in mice lacking a functional Hnf1a gene (Boj et al. 2001).

Literature References
PubMed ID Title Journal Year
11287626 Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

Parrizas, M, Maestro, MA, Boj, SF, Paniagua, A, Casamitjana, R, Gomis, R, Rivera, F, Ferrer, J

Mol Cell Biol 2001
11717395 A transcription factor regulatory circuit in differentiated pancreatic cells

Boj, SF, Parrizas, M, Maestro, MA, Ferrer, J

Proc Natl Acad Sci U S A 2001
9822613 Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line

Wang, H, Maechler, P, Hagenfeldt, KA, Wollheim, CB

EMBO J 1998
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