Reactome | Adaptor protein complex 2 (AP-2) large adaptins [cytosol]

Adaptor protein complex 2 (AP-2) large adaptins [cytosol]

Stable Identifier

R-MMU-182144

Type

Set [DefinedSet]

Species

Mus musculus

Compartment

cytosol

Locations in the PathwayBrowser

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Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        AP2:chlorpromazine [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - AP2 binds chlorpromazine (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        AP2:chlorpromazine [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)
      - AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin-coated vesicle [cytosol] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - Recruitment of AP-2 complex and clathrin (Mus musculus)
      - AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)
        
        p-T156 AP-2 Complex [cytosol] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Mus musculus)

Participants

members

Participates

as a component of

Inferred From

Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)

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