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beta-NGF [extracellular region]
Stable Identifier
R-MMU-181839
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NADE modulates death signalling (Mus musculus)
14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR binds to NADE (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR:NADE promotes caspase2/3 activation (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NRIF signals cell death from the nucleus (Mus musculus)
TRAF6 binds to p75NTR:NRIF (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NFG and proNGF binds to p75NTR (Mus musculus)
NGF homodimer binds to p75NTR (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR regulates axonogenesis (Mus musculus)
Axonal growth stimulation (Mus musculus)
NGF binding to p75NTR inactivates RHOA (Mus musculus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IKK-beta is recruited (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
MYD88 dissociates (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
TRAF6 is auto-ubiquitinated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p62 is recruited and forms a complex with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p62 recruits an atypical PKC (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
p75NTR interacts with RIP2 (Mus musculus)
NGF:p75NTR:RIP2 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Expression and Processing of Neurotrophins (Mus musculus)
NGF processing (Mus musculus)
Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Activation of TRKA receptors (Mus musculus)
TRKA activation by NGF (Mus musculus)
Activated TrkA receptor internalizes to endosomes (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
The bound receptor dimerizes (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
beta-NGF dimer binds to TrkA receptor (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
PI3K/AKT activation (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Retrograde neurotrophin signalling (Mus musculus)
Axonal transport of NGF:Trk complexes (Mus musculus)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
ARMS-mediated activation (Mus musculus)
ARMS is phosphorylated by active TrkA receptor (Mus musculus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
C3G stimulates nucleotide exchange on Rap1 (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
Crk's SH3 domain engages C3G (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P01139 Ngf
Gene Names
Ngf, Ngfb
Chain
signal peptide:1-18, propeptide:19-121, chain:122-241
Reference Genes
BioGPS Gene:18049 Ngf
KEGG:mmu:18049 Ngf
Monarch:18049 Ngf
NCBI Gene:18049 Ngf
UCSC:P01139 Ngf
Reference Transcript
RefSeq:XM_006501108.3 Ngf
RefSeq:NM_013609.3 Ngf
RefSeq:NM_001112698.2 Ngf
Other Identifiers
102298_at
10494817
1419675_at
17401066
18049
4357502
4398995
4434209
4486965
4544663
5129885
5163657
5196467
5334168
5533471
5601758
A_51_P381208
A_55_P2074337
GE36704
GO:0004857
GO:0005102
GO:0005163
GO:0005576
GO:0005615
GO:0005768
GO:0005788
GO:0007165
GO:0007169
GO:0007422
GO:0007623
GO:0008021
GO:0008083
GO:0008191
GO:0008289
GO:0008625
GO:0010628
GO:0010976
GO:0014042
GO:0019233
GO:0021675
GO:0030297
GO:0030414
GO:0030424
GO:0030425
GO:0031175
GO:0031398
GO:0031410
GO:0031904
GO:0038180
GO:0043069
GO:0043524
GO:0045664
GO:0045773
GO:0046579
GO:0046928
GO:0048011
GO:0048018
GO:0048672
GO:0048675
GO:0048812
GO:0048856
GO:0050804
GO:0050877
GO:0051279
GO:0051388
GO:0051402
GO:0051897
GO:0070374
GO:0097192
GO:0098772
ILMN_2660233
ILMN_2937596
m14805_s_at
mMC017465
Participates
as a component of
beta-NGF homodimer:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
beta-NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
as a member of
NGF [extracellular region] (Mus musculus)
Other forms of this molecule
pro-beta-NGF [extracellular region]
NGF(19-241) [extracellular region]
NGF [Golgi lumen]
NGF [cytosol]
pro-beta-NGF precursor [endoplasmic reticulum lumen]
pre-pro-beta-NGF precursor [endoplasmic reticulum lumen]
NGF(19-241) [Golgi lumen]
Inferred From
NGF [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_038637.1
,
NP_001106168.1
,
XP_006501171.1
ENSEMBL
ENSMUSP00000040345
,
ENSMUST00000035952
,
ENSMUSG00000027859
PRO
P01139
GlyGen
P01139
MGI
97321
HMDB Protein
HMDBP13922
PDB
4XPJ
,
1BET
,
1BTG
,
1SGF
,
3IJ2
,
4EAX
,
6FFY
,
5LSD
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