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Apoa1 [extracellular region]
Stable Identifier
R-MMU-174720
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
APOA1(25-266), Q00623
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Heme signaling (Mus musculus)
FeHM oxidises LDL,HDL (Mus musculus)
LDL,HDL [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
oxidized LDL,HDL [extracellular region] (Mus musculus)
oxidized discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
oxidized spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
Release of platelet secretory granule components (Mus musculus)
Platelet releasate secretory granule proteins [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of fat-soluble vitamins (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
CR:atREs binds apoE and HSPG (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
CR:atREs:HSPG:apoE [plasma membrane] (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Cytosolic CMs translocate to extracellular region (Mus musculus)
nascent CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LPL hydrolyses TGs from mature CMs (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
mature CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)
CR:atREs:HSPG:apoE [plasma membrane] (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Nascent CMs transform into mature CMs (Mus musculus)
mature CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
nascent CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
Retinoid metabolism and transport (Mus musculus)
CR:atREs binds apoE and HSPG (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
CR:atREs:HSPG:apoE [plasma membrane] (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Cytosolic CMs translocate to extracellular region (Mus musculus)
nascent CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LPL hydrolyses TGs from mature CMs (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
mature CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)
CR:atREs:HSPG:apoE [plasma membrane] (Mus musculus)
CR:atREs [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Nascent CMs transform into mature CMs (Mus musculus)
mature CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
nascent CM:atREs [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Transport of small molecules (Mus musculus)
Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
Plasma lipoprotein assembly (Mus musculus)
Chylomicron assembly (Mus musculus)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Mus musculus)
chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
nascent chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)
nascent chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
HDL assembly (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
pre-beta HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Plasma lipoprotein clearance (Mus musculus)
HDL clearance (Mus musculus)
Disassembly of SR-BI-bound spherical HDL (Mus musculus)
pre-beta HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
HDLBP binds HDL (Mus musculus)
HDLBP:HDL [plasma membrane] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Plasma lipoprotein remodeling (Mus musculus)
Chylomicron remodeling (Mus musculus)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
chylomicron [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
HDL remodeling (Mus musculus)
Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
discoidal HDL:cholesterol [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)
LCAT:discoidal HDL complex [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)
LCAT:spherical HDL complex [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)
LCAT:discoidal HDL complex [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)
LCAT:spherical HDL complex [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Spherical HDL binds C and E apolipoproteins (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)
enlarged spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Vesicle-mediated transport (Mus musculus)
Binding and Uptake of Ligands by Scavenger Receptors (Mus musculus)
Scavenging by Class A Receptors (Mus musculus)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)
MSR1:Ligand [plasma membrane] (Mus musculus)
Ligands of MSR1 [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Scavenging by Class B Receptors (Mus musculus)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)
Platelet glycoprotein IV:Ligand [plasma membrane] (Mus musculus)
Ligands of CD36 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)
Ligands of SCARB1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
SCARB1:Ligand [plasma membrane] (Mus musculus)
Ligands of SCARB1 [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Scavenging of heme from plasma (Mus musculus)
Haptoglobin-related Protein binds Hemoglobin (Mus musculus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Mus musculus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Mus musculus)
Apoa1 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:Q00623 Apoa1
Gene Names
Apoa1
Chain
signal peptide:1-18, chain:19-264, chain:25-264, chain:25-263
Reference Genes
BioGPS Gene:11806 Apoa1
ENSEMBL:ENSMUSG00000032083.9 Apoa1
KEGG Gene (Mus musculus):11806 Apoa1
Monarch:11806 Apoa1
NCBI Gene:11806 Apoa1
UCSC:Q00623 Apoa1
Reference Transcript
RefSeq:NM_009692.4 Apoa1
Other Identifiers
10585005
11806
1419232_a_at
1419233_x_at
1438840_x_at
1455201_x_at
17516901
4515990
4750115
4790258
5179074
5186558
5297394
5306000
5415898
5442851
96094_at
A_51_P408082
GE35080
GO:0001540
GO:0001932
GO:0001935
GO:0002376
GO:0002719
GO:0005102
GO:0005215
GO:0005319
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005829
GO:0006629
GO:0006644
GO:0006656
GO:0006695
GO:0006869
GO:0006954
GO:0007010
GO:0007155
GO:0007186
GO:0007229
GO:0008035
GO:0008202
GO:0008203
GO:0008211
GO:0008289
GO:0009986
GO:0010804
GO:0010875
GO:0010903
GO:0015485
GO:0015914
GO:0016192
GO:0018158
GO:0018206
GO:0019899
GO:0019915
GO:0022600
GO:0023052
GO:0030139
GO:0030300
GO:0030301
GO:0030325
GO:0031072
GO:0031100
GO:0031410
GO:0032489
GO:0032691
GO:0033344
GO:0033700
GO:0034115
GO:0034190
GO:0034191
GO:0034361
GO:0034362
GO:0034363
GO:0034364
GO:0034365
GO:0034366
GO:0034375
GO:0034380
GO:0035025
GO:0036211
GO:0042157
GO:0042158
GO:0042632
GO:0042802
GO:0042803
GO:0043226
GO:0043534
GO:0043691
GO:0045499
GO:0046470
GO:0048018
GO:0048856
GO:0048870
GO:0050728
GO:0050766
GO:0050821
GO:0050919
GO:0051180
GO:0051496
GO:0055091
GO:0055102
GO:0060228
GO:0060354
GO:0060761
GO:0061024
GO:0065003
GO:0070328
GO:0070508
GO:0070653
GO:0071813
GO:0090205
GO:0098772
GO:0120009
GO:0120020
GO:1900026
GO:1902995
ILMN_2623393
mMC020418
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Mus musculus)
Ligands of MSR1 [extracellular region] (Mus musculus)
as a component of
nascent CM:atREs [extracellular region] (Mus musculus)
mature CM:atREs [extracellular region] (Mus musculus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Mus musculus)
TG-depleted chylomicron [extracellular region] (Mus musculus)
enlarged spherical HDL [extracellular region] (Mus musculus)
chylomicron [extracellular region] (Mus musculus)
nascent chylomicron [extracellular region] (Mus musculus)
pre-beta HDL [extracellular region] (Mus musculus)
HPR:APOL1:APOA1:HDL3 [extracellular region] (Mus musculus)
oxidized spherical HDL [extracellular region] (Mus musculus)
oxidized discoidal HDL [extracellular region] (Mus musculus)
discoidal HDL [extracellular region] (Mus musculus)
spherical HDL [extracellular region] (Mus musculus)
as an input of
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)
as an output of
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)
This entity regulates
Positively
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
(Mus musculus)
Other forms of this molecule
Apoa1 [secretory granule lumen]
Apoa1 [cytosol]
Apoa1 [cytosol]
Apoa1 [early endosome]
Apoa1 [endoplasmic reticulum lumen]
Apoa1 [extracellular region]
Apoa1 [plasma membrane]
Apoa1 [extracellular region]
Apoa1 [endocytic vesicle lumen]
phospho-Apoa1 [endoplasmic reticulum lumen]
Apoa1 [endoplasmic reticulum lumen]
Inferred From
APOA1(25-266) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_033822.2
Ensembl
ENSMUSP00000034588
,
ENSMUSG00000032083
,
ENSMUST00000034588
PRO
Q00623
MGI
88049
PDB
2LEM
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08460 Kcnma1
2
Kcnma1 [plasma membrane]
(R-MMU-9667781)
KCNMA1 [plasma membrane]
(R-MMU-418462)
0.556
4
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