Reactome | PSMC1 [nucleoplasm]

PSMC1 [nucleoplasm]

Stable Identifier

R-MMU-174338

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P62192

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'on' state (Mus musculus)
    - GLI2,3 are degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1:PSMD2 [nucleoplasm] (Mus musculus)
        
        PSMC2:PSMC1 [nucleoplasm] (Mus musculus)
        
        PSMC1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P62192 Psmc1

Gene Names

Psmc1

Chain

initiator methionine:1, chain:2-440

Reference Genes

BioGPS Gene:19179 Psmc1

KEGG:mmu:19179 Psmc1

Monarch:19179 Psmc1

NCBI Gene:19179 Psmc1

UCSC:P62192 Psmc1

Reference Transcript

RefSeq:NM_008947.3 Psmc1

Other Identifiers

10397741

10439878

1416005_at

160152_at

17277907

19179

4399192

4422441

4558760

4724562

4809108

4834268

4984471

5006592

5172272

5221320

5323799

5345339

5381552

5420339

5491834

5510212

5512678

5515824

5524976

A_51_P104960

A_55_P2033863

A_66_P100699

GE34279

GO:0000166

GO:0000502

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0036402

GO:0043161

GO:1901800

ILMN_1226110

ILMN_2707503

ILMN_2707504

U39302_s_at

mMC019571

Participates

as a component of

PSMC2:PSMC1 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Psmc1 [cytosol]

Inferred From

PSMC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032973.1

ENSEMBL

ENSMUSP00000021595, ENSMUST00000021595, ENSMUSG00000021178

PRO

P62192

GlyGen

P62192

MGI

106054

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