Reactome | PSMC5 [nucleoplasm]

PSMC5 [nucleoplasm]

Stable Identifier

R-MMU-174312

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P62196

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Mus musculus)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)
        
        USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Mus musculus)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'on' state (Mus musculus)
    - GLI2,3 are degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        PSMC4:PSMC5 [nucleoplasm] (Mus musculus)
        
        PSMC5 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P62196 Psmc5

Gene Names

Psmc5, Sug1

Chain

initiator methionine:1, chain:2-406

Reference Genes

BioGPS Gene:19184 Psmc5

KEGG:mmu:19184 Psmc5

Monarch:19184 Psmc5

NCBI Gene:19184 Psmc5

UCSC:P62196 Psmc5

Reference Transcript

RefSeq:NM_008950.1 Psmc5

Other Identifiers

10338486

10339106

10340453

10340509

10340959

10341466

10341611

10342732

10342902

10343635

10344106

10344560

10382069

1415740_at

160534_at

17257554

19184

4501149

4548870

4629861

4649757

4743172

4913755

5135447

5165333

5202355

5208642

5286209

5419389

5456813

5521782

5537880

93438_f_at

A_51_P232355

A_52_P657435

GE42552

GO:0000166

GO:0000502

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005675

GO:0005737

GO:0005838

GO:0006355

GO:0006357

GO:0008540

GO:0016234

GO:0016787

GO:0016887

GO:0017025

GO:0022624

GO:0030163

GO:0031410

GO:0031531

GO:0031595

GO:0031597

GO:0036402

GO:0043161

GO:0045892

GO:0090261

GO:0140296

GO:0140297

GO:1901800

ILMN_1220632

ILMN_1251877

M60510_s_at

Z54219_s_at

mMC009711

Participates

as a component of

Other forms of this molecule

Psmc5 [cytosol]

Inferred From

PSMC5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032976.1

ENSEMBL

ENSMUSP00000021049, ENSMUSG00000020708, ENSMUST00000021049

PRO

P62196

GlyGen

P62196

MGI

105047

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.581	6

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