Reactome | Anapc4 [cytosol]

Anapc4 [cytosol]

Stable Identifier

R-MMU-174168

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ANAPC4, Q91W96

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Cyclin B (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Securin (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
        
        APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
        
        Association of Nek2A with MCC:APC/C (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Nek2A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Multiubiquitination of Nek2A (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
        
        Association of Cyclin A with the APC/C (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Degradation multiubiquitinated Cyclin A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
        
        Association of Cdh1 with the APC/C (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        Dissociation of Cdc20 from APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Anapc4 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91W96

Gene Names

Anapc4

Reference Genes

BioGPS Gene:52206 Anapc4

ENSEMBL:ENSMUSG00000029176

KEGG:mmu:52206 Anapc4

Monarch:52206 Anapc4

NCBI Gene:52206 Anapc4

UCSC:Q91W96 Anapc4

Reference Transcript

RefSeq:NM_024213.2 Anapc4

Other Identifiers

10521863

1423930_at

1423931_s_at

17437425

4376439

4432622

4446831

4532743

4534260

4599629

4602377

4647369

4667098

4690721

4708594

4711644

4748204

4757526

4761526

4777597

4784750

4797739

4871389

4879248

4968803

4970095

4979800

5036073

5039132

5059084

5113057

5141612

5143456

5150449

5165263

5171231

5179348

5183783

52206

5223183

5229713

5296790

5322558

5449212

5463564

5476833

5487358

5502932

5507053

5528970

5529581

5542867

5572139

5582827

5595637

5600247

94954_at

A_52_P237451

A_55_P2720913

GE121050

GO:0005515

GO:0005634

GO:0005680

GO:0016567

GO:0019903

GO:0030071

GO:0030163

GO:0031145

GO:0034399

GO:0051301

GO:0070936

GO:0070979

GO:0141198

ILMN_2740392

ILMN_2859778

aa185352_s_at

mMC017383

Participates

as a component of

Other forms of this molecule

Anapc4 [nucleoplasm]

Inferred From

ANAPC4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_077175.1

ENSEMBL

ENSMUSP00000031072, ENSMUSG00000029176, ENSMUST00000031072

PRO

Q91W96

MGI

1098673

Cite Us!