Reactome | ANAPC11 [cytosol]

ANAPC11 [cytosol]

Stable Identifier

R-MMU-174126

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q9CPX9

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Cyclin B (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Securin (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
        
        APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
        
        Association of Nek2A with MCC:APC/C (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Nek2A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Multiubiquitination of Nek2A (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
        
        Association of Cyclin A with the APC/C (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Degradation multiubiquitinated Cyclin A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
        
        Association of Cdh1 with the APC/C (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        Dissociation of Cdc20 from APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        ANAPC11 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CPX9

Reference Genes

BioGPS Gene:66156

ENSEMBL:ENSMUSG00000025135

KEGG:mmu:66156

Monarch:66156

NCBI Gene:66156

UCSC:Q9CPX9

Reference Transcript

Other Identifiers

10383423

10383429

115302_at

1417326_a_at

1440240_at

1459212_at

17259422

17259430

4349338

4522743

4546879

4574101

4608163

4618178

4726893

4772264

4818288

4831810

4919976

5074738

5151635

5225703

5346755

5559598

5574020

5578652

66156

93967_at

A_51_P121390

A_51_P300666

A_52_P238019

A_52_P635984

A_55_P1952071

A_55_P1952076

A_55_P1961089

A_55_P2720376

GE136722

GE40721

GO:0001664

GO:0003824

GO:0004842

GO:0005634

GO:0005654

GO:0005680

GO:0005730

GO:0005737

GO:0006511

GO:0008270

GO:0016567

GO:0016740

GO:0030163

GO:0031145

GO:0031146

GO:0031461

GO:0034450

GO:0043161

GO:0045842

GO:0046872

GO:0051301

GO:0061630

GO:0070936

GO:0070979

GO:0097602

GO:0140096

GO:0141198

ILMN_1237597

ILMN_2635572

ILMN_3099265

mMC016341

mMC016733

Participates

as a component of

Other forms of this molecule

ANAPC11 [nucleoplasm]

Inferred From

ANAPC11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001033319.1, NP_079665.1

ENSEMBL

ENSMUSP00000026128, ENSMUST00000026128, ENSMUST00000093140, ENSMUSP00000097714, ENSMUSG00000025135

PRO

Q9CPX9

MGI

1913406

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