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TGFBR2 [plasma membrane]
Stable Identifier
R-MMU-170842
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
Q62312
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
CBL binds TGFBR2 (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2:CBL [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
CBL neddylates TGFBR2 (Mus musculus)
TGFBR2:CBL [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Dimeric TGF-beta-1 binds to the receptor (Mus musculus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Degradation of TGF-beta receptor complex (Mus musculus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 phosphorylates TGFBR1 (Mus musculus)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 recruits TGFBR1 (Mus musculus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Mus musculus)
Disassembly of tight junctions (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
SMURF1 binds phosphorylated PARD6A (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
SMURF1 ubiquitinates RHOA (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
Signaling by TGFBR3 (Mus musculus)
TGFBR3 regulates TGF-beta signaling (Mus musculus)
Endocytosis of TGFBR3:ARRB complex (Mus musculus)
pTGFBR3-complex:ARBB_endo [endocytic vesicle membrane] (Mus musculus)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
pTGFBR3-complex:ARRB [plasma membrane] (Mus musculus)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR3 binding to ARRB1/2 (Mus musculus)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
pTGFBR3-complex:ARRB [plasma membrane] (Mus musculus)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR3 complex binds to TGFBR2 (Mus musculus)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR3 phosphorylation by TGFBR2 complex (Mus musculus)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62312
Reference Genes
BioGPS Gene:21813
ENSEMBL:ENSMUSG00000032440
ENSEMBL:ENSMUSG00000032440.14
KEGG Gene (Mus musculus):21813
Monarch:21813
NCBI Gene:21813
UCSC:Q62312
Reference Transcript
RefSeq:NM_029575.3
RefSeq:NM_009371.3
Other Identifiers
10597518
1425444_a_at
1426397_at
162600_at
17531987
21813
4403328
4429229
4513947
4628262
4737472
4878163
4908163
4997515
5019308
5129496
5151653
5154954
5478237
5539744
A_51_P450573
A_55_P2107288
GE125125
GO:0000166
GO:0001569
GO:0001570
GO:0001701
GO:0001837
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003180
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005026
GO:0005515
GO:0005524
GO:0005539
GO:0005576
GO:0005615
GO:0005886
GO:0005901
GO:0006468
GO:0006898
GO:0006915
GO:0007155
GO:0007178
GO:0007179
GO:0007219
GO:0007224
GO:0007369
GO:0007420
GO:0007507
GO:0008285
GO:0009410
GO:0009887
GO:0009897
GO:0009986
GO:0010468
GO:0010634
GO:0010718
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0017002
GO:0019209
GO:0023052
GO:0030154
GO:0030324
GO:0031435
GO:0032924
GO:0034713
GO:0034714
GO:0035162
GO:0035909
GO:0036211
GO:0038023
GO:0042127
GO:0043235
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048185
GO:0048661
GO:0048701
GO:0048844
GO:0048856
GO:0048870
GO:0050431
GO:0051138
GO:0051216
GO:0060021
GO:0060044
GO:0060089
GO:0060090
GO:0060391
GO:0060395
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0061520
GO:0062009
GO:0070021
GO:0070723
GO:0071363
GO:0072091
GO:0098772
GO:0140096
GO:1905007
GO:1905317
GO:1990086
GO:1990428
GO:2000379
GO:2000563
GO:2000736
ILMN_1242086
ILMN_2760979
ILMN_2777917
mMC025881
mMR027560
Participates
as an input of
TGFBR3 complex binds to TGFBR2 (Mus musculus)
CBL binds TGFBR2 (Mus musculus)
Dimeric TGF-beta-1 binds to the receptor (Mus musculus)
as a component of
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2:CBL [plasma membrane] (Mus musculus)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Mus musculus)
TGFBR2 homodimer [plasma membrane] (Mus musculus)
Other forms of this molecule
NEDD8-K556,K567-TGFBR2 [plasma membrane]
Inferred From
TGFBR2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_033397.3
,
NP_083851.3
IntEnz
2.7.11.30
Ensembl
ENSMUST00000061101
,
ENSMUSP00000062333
,
ENSMUSP00000035014
,
ENSMUST00000035014
,
ENSMUSG00000032440
PRO
Q62312
MGI
98729
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q64729
3
Ub-TGFBR1 [plasma membrane]
(R-MMU-8869461)
TGFBR1 [plasma membrane]
(R-MMU-170839)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane]
(R-MMU-170849)
0.667
3
UniProt:P98083-2 Shc1
3
p-Y-Shc1-2 [cytosol]
(R-MMU-9036934)
Shc1-2 [cytosol]
(R-MMU-9030467)
p-Y239,Y240,Y313-Shc1 [cytosol]
(R-MMU-1169449)
0.576
3
UniProt:Q8TDM6 DLG5
1
DLG5 [plasma membrane]
(R-HSA-9715164)
0.537
3
UniProt:P98083-1 SHC1
0.499
2
UniProt:P55284 Cdh5
3
Cdh5 [plasma membrane]
(R-MMU-9860478)
phospho-p-S665-VE-cadherin [plasma membrane]
(R-MMU-5357435)
VE-cadherin [plasma membrane]
(R-MMU-418992)
0.463
4
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