Akt2 Phosphorylates Myosin 5a

Stable Identifier
R-MMU-1449591
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
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Akt2 Phosphorylates Myosin 5a
In response to insulin Akt2 phosphorylates Myosin 5a on serine-1650, which promotes association of Myosin 5a with actin and activates ATPase activity (and presumably motor activity) of Myosin 5a (Yoshizaki et al. 2007).
Literature References
PubMed ID Title Journal Year
17515613 Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation

Yoshizaki, T, Imamura, T, Babendure, JL, Lu, JC, Sonoda, N, Olefsky, JM

Mol Cell Biol 2007
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T309, S474-Akt2 [plasma membrane]

Physical Entity
p-T309, S474-Akt2 [plasma membrane] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-AKT2 phosphorylates Myosin 5A (Homo sapiens)
Authored
May, B  (2011-07-13)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-15)
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