Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHEK2 [nucleoplasm]
Stable Identifier
R-MMU-113824
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q9Z265
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
CHEK2 is recruited to DNA DSBs (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
Phosphorylation and activation of CHEK2 by ATM (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
CHEK2 is recruited to DNA DSBs (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
Phosphorylation and activation of CHEK2 by ATM (Mus musculus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
CHEK2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z265
Reference Genes
BioGPS Gene:50883
ENSEMBL:ENSMUSG00000029521
ENSEMBL:ENSMUSG00000029521.8
KEGG Gene (Mus musculus):50883
Monarch:50883
NCBI Gene:50883
UCSC:Q9Z265
Reference Transcript
RefSeq:XM_006535070.2
RefSeq:NM_016681.3
RefSeq:XM_006535069.2
Other Identifiers
10524266
1422747_at
17440575
4467160
4493974
4565134
4570707
4620486
4624643
4700592
4833225
4842308
4894032
4937387
5043179
50883
5130289
5143211
5155919
5360378
5582127
92481_at
A_51_P137111
A_52_P117090
GE36998
GO:0000077
GO:0000086
GO:0000166
GO:0000278
GO:0000781
GO:0001934
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006974
GO:0006978
GO:0007010
GO:0007049
GO:0007059
GO:0008630
GO:0010332
GO:0012501
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0019901
GO:0023052
GO:0030163
GO:0031573
GO:0031625
GO:0036211
GO:0042176
GO:0042770
GO:0042771
GO:0042802
GO:0042803
GO:0043226
GO:0044773
GO:0045893
GO:0046777
GO:0046872
GO:0050821
GO:0051301
GO:0070242
GO:0071480
GO:0090307
GO:0106310
GO:0140014
GO:0140096
GO:2000002
GO:2000210
ILMN_1247062
ILMN_2633492
ILMN_2856599
mMC000831
Participates
as an input of
CHEK2 is recruited to DNA DSBs (Mus musculus)
as a component of
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Mus musculus)
Other forms of this molecule
phospho-p-T68-CHEK2 [nucleoplasm]
phospho-p-S,3T-CHEK2 [nucleoplasm]
Inferred From
CHEK2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_057890.1
,
XP_006535133.1
,
XP_006535132.1
Ensembl
ENSMUSG00000029521
,
ENSMUST00000066160
,
ENSMUSP00000066679
PRO
Q9Z265
MGI
1355321
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text