GATA3 binds the IL5 gene

Stable Identifier
R-HSA-9976390
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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GATA3 binds the IL5 gene
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GATA3 binds 3 sites in the proximal 400 bp of the IL5 promoter (Schwenger et al. 2001, Ahlfors et al. 2010, Upadhyaya et al. 2011, Kanhere et al. 2012, inferred from mouse homologs in Siegel et al. 1995, Zhang et al. 1997, Lee et al. 1998, Zhang et al. 1998, Horiuchi et al. 2011, Wei et al. 2011, Sasaki et al. 2013). Only about 20% of Th2 cells express IL5 and these appear to be more highly differentiated and have a higher level of GATA3 bound to the IL5 promoter (Upadhyaya et al. 2011).
Literature References
PubMed ID Title Journal Year
21849680 Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells

Upadhyaya, B, Yin, Y, Hill, BJ, Douek, DC, Prussin, C

J Immunol 2011
11579103 GATA-3 has dual regulatory functions in human interleukin-5 transcription

Schwenger, GT, Fournier, R, Kok, CC, Mordvinov, VA, Yeoman, D, Sanderson, CJ

J Biol Chem 2001
20522714 SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

Ahlfors, H, Limaye, A, Elo, LL, Tuomela, S, Burute, M, Gottimukkala, KV, Notani, D, Rasool, O, Galande, S, Lahesmaa, R

Blood 2010
23232398 T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

Kanhere, A, Hertweck, A, Bhatia, U, Gökmen, MR, Perucha, E, Jackson, I, Lord, GM, Jenner, RG

Nat Commun 2012
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Gata3 binds the Il5 gene (Mus musculus)
Authored
May, B  (2025-12-11)
Reviewed
Barbutti, I  (2026-02-24)
Lord, GM  (2026-02-26)
Created
May, B  (2025-12-11)
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