Reactome | PGK1 phosphorylates AKT1S1

PGK1 phosphorylates AKT1S1

Stable Identifier

R-HSA-9975250

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphoglycerate kinase 1 (PGK1) can act as a protein serine/threonine kinase that, under normoxia conditions, phosphorylates AKT1S1 (PRAS40) on threonine residue T246, which suppresses autophagy-mediated cell death and promotes cellular proliferation (Zhang et al. 2022).

Literature References

PubMed ID	Title	Journal	Year
35058442	PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40 Zhang, T, Wang, Y, Yu, H, Zhang, T, Guo, L, Xu, J, Wei, X, Wang, N, Wu, Y, Wang, X, Huang, L	Cell Death Dis	2022