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p-Y165-ARHGEF4 [cytosol]
Stable Identifier
R-HSA-9968120
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y165-ASEF
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Activation of STAT3 by cadherin engagement (Homo sapiens)
SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) (Homo sapiens)
SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs (Homo sapiens)
SRC-phosphorylated RAC1/CDC42 GEFs [cytosol] (Homo sapiens)
SRC-phosphorylated RAC1 GEFs [cytosol] (Homo sapiens)
p-Y165-ARHGEF4 [cytosol] (Homo sapiens)
SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42) (Homo sapiens)
SRC-phosphorylated RAC1/CDC42 GEFs [cytosol] (Homo sapiens)
SRC-phosphorylated RAC1 GEFs [cytosol] (Homo sapiens)
p-Y165-ARHGEF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NR80 ARHGEF4
Gene Names
ARHGEF4, KIAA1112
Chain
chain:1-690
Reference Genes
BioGPS Gene:50649 ARHGEF4
COSMIC - genes:ARHGEF4 ARHGEF4
CTD Gene:50649 ARHGEF4
dbSNP Gene:50649 ARHGEF4
ENSEMBL:ENSG00000136002 ARHGEF4
HGNC:684 ARHGEF4
KEGG:hsa:50649 ARHGEF4
Monarch:50649 ARHGEF4
NCBI Gene:50649 ARHGEF4
OMIM:605216 ARHGEF4
UCSC:Q9NR80 ARHGEF4
Reference Transcript
RefSeq:NM_015320.3 ARHGEF4
Participates
as a candidate of
SRC-phosphorylated RAC1 GEFs [cytosol] (Homo sapiens)
Other forms of this molecule
ARHGEF4 [cytosol]
Inferred To
phospho-ARHGEF4 [cytosol]
(Bos taurus)
phospho-ARHGEF4 [cytosol]
(Canis familiaris)
phospho-ARHGEF4 [cytosol]
(Gallus gallus)
phospho-Arhgef4 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 165
Coordinate
165
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_056135.2
ENSEMBL
ENSP00000316845
,
ENSP00000348017
,
ENSG00000136002
,
ENST00000326016
,
ENST00000355771
OpenTargets
ENSG00000136002
GeneCards
ARHGEF4
HPA
ENSG00000136002-ARHGEF4
PRO
Q9NR80
Pharos - Targets
Q9NR80
HMDB Protein
HMDBP11493
PDB
3NMZ
,
2PZ1
,
2DX1
,
3NMX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.615
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
2
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