Reactome | hormone receptor positive mammary luminal epithelial cell

hormone receptor positive mammary luminal epithelial cell

Stable Identifier

R-HSA-9960188

Type

Cell

Species

Homo sapiens

Synonyms

luminal hormone sensing cell

Locations in the PathwayBrowser

Expand all

Cytology

Organ

mammary gland (UBERON:0001911)

Tissue

parenchyma of mammary gland (UBERON:0036245)

Cell Type

luminal epithelial cell of mammary gland (CL:0002326)

Markers

Protein

ESR1 [nucleoplasm] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.

KRT18 [cytosol] (Homo sapiens)

- Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.Breast Cancer Res Treat67,93-109(2001)Stingl, J., Eaves, CJ., Zandieh, I., Emerman, JT.
- An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: Normal breast and benign proliferative lesions.Virchows Arch A Pathol Anat Histopathol421,315-22(1992)Böcker, W., Bier, B., Freytag, G., Brömmelkamp, B., Jarasch, ED., Edel, G., Dockhorn-Dworniczak, B., Schmid, KW.

ANKRD30A [nucleoplasm] (Homo sapiens)

- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.

PGR [nucleoplasm] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.

KRT19 [cytosol] (Homo sapiens)

- Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.Breast Cancer Res Treat67,93-109(2001)Stingl, J., Eaves, CJ., Zandieh, I., Emerman, JT.
- An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: Normal breast and benign proliferative lesions.Virchows Arch A Pathol Anat Histopathol421,315-22(1992)Böcker, W., Bier, B., Freytag, G., Brömmelkamp, B., Jarasch, ED., Edel, G., Dockhorn-Dworniczak, B., Schmid, KW.

EPCAM [plasma membrane] (Homo sapiens)

- Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology.J Mammary Gland Biol Neoplasia25,367-387(2020)Martin Carli, JF., Trahan, GD., Jones, KL., Hirsch, N., Rolloff, KP., Dunn, EZ., Friedman, JE., Barbour, LA., Hernandez, TL., Maclean, PS., Monks, J., McManaman, JL., Rudolph, MC.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.Breast Cancer Res12,R21(2010)Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, ML., Vaillant, F., Yagita, H., Lindeman, GJ., Smyth, GK., Visvader, JE.
- A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors.Sci Rep9,14843(2019)Ísberg, ÓG., Kim, J., Fridriksdottir, AJ., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, L., Petersen, OW., Villadsen, R.
- Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.Mol Cancer Res17,1556-1570(2019)Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, KD., Storniolo, AM., Nakshatri, H.

KRT8 [cytosol] (Homo sapiens)

- Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.Breast Cancer Res Treat67,93-109(2001)Stingl, J., Eaves, CJ., Zandieh, I., Emerman, JT.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: Normal breast and benign proliferative lesions.Virchows Arch A Pathol Anat Histopathol421,315-22(1992)Böcker, W., Bier, B., Freytag, G., Brömmelkamp, B., Jarasch, ED., Edel, G., Dockhorn-Dworniczak, B., Schmid, KW.

RNA

AREG mRNA [cytosol] (Homo sapiens)

- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors.Sci Rep9,14843(2019)Ísberg, ÓG., Kim, J., Fridriksdottir, AJ., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, L., Petersen, OW., Villadsen, R.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

CDH1 mRNA [cytosol] (Homo sapiens)

- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

KRT19 mRNA [cytosol] (Homo sapiens)

- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.

ESR1 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.
- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.Breast Cancer Res12,R21(2010)Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, ML., Vaillant, F., Yagita, H., Lindeman, GJ., Smyth, GK., Visvader, JE.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

EPCAM mRNA [cytosol] (Homo sapiens)

- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

KRT18 mRNA [cytosol] (Homo sapiens)

- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.

KRT8 mRNA [cytosol] (Homo sapiens)

- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.

PGR mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.
- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.Breast Cancer Res12,R21(2010)Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, ML., Vaillant, F., Yagita, H., Lindeman, GJ., Smyth, GK., Visvader, JE.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

FOXA1 mRNA [cytosol] (Homo sapiens)

- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.Breast Cancer Res12,R21(2010)Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, ML., Vaillant, F., Yagita, H., Lindeman, GJ., Smyth, GK., Visvader, JE.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors.Sci Rep9,14843(2019)Ísberg, ÓG., Kim, J., Fridriksdottir, AJ., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, L., Petersen, OW., Villadsen, R.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

ANKRD30A mRNA [cytosol] (Homo sapiens)

- Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.Nat Commun9,2028(2018)Nguyen, QH., Pervolarakis, N., Blake, K., Ma, D., Davis, RT., James, N., Phung, AT., Willey, E., Kumar, R., Jabart, E., Driver, I., Rock, J., Goga, A., Khan, SA., Lawson, DA., Werb, Z., Kessenbrock, K.
- A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.Cell Rep Med2,100219(2021)Bhat-Nakshatri, P., Gao, H., Sheng, L., McGuire, PC., Xuei, X., Wan, J., Liu, Y., Althouse, SK., Colter, A., Sandusky, G., Storniolo, AM., Nakshatri, H.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.Nat Genet56,652-662(2024)Reed, AD., Pensa, S., Steif, A., Stenning, J., Kunz, DJ., Porter, LJ., Hua, K., He, P., Twigger, AJ., Siu, AJQ., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, JJ., Speirs, V., Jones, JL., Marioni, JC., Khaled, WT.

Participates

as an output of

Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell (Homo sapiens)

This entity regulates

Positively

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