Reactome | hormone receptor positive mammary luminal progenitor cell

hormone receptor positive mammary luminal progenitor cell

Stable Identifier

R-HSA-9960159

Type

Cell

Species

Homo sapiens

Locations in the PathwayBrowser

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Cytology

Organ

mammary gland (UBERON:0001911)

Tissue

parenchyma of mammary gland (UBERON:0036245)

Cell Type

progenitor cell of mammary luminal epithelium (CL:0009116)

Markers

Protein

MUC1(24-1255) [plasma membrane] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.Breast Cancer Res Treat67,93-109(2001)Stingl, J., Eaves, CJ., Zandieh, I., Emerman, JT.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.
- Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast.Differentiation63,201-13(1998)Stingl, J., Eaves, CJ., Kuusk, U., Emerman, JT.

ESR1 [nucleoplasm] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.

KRT18 [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.

EPCAM [plasma membrane] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology.J Mammary Gland Biol Neoplasia25,367-387(2020)Martin Carli, JF., Trahan, GD., Jones, KL., Hirsch, N., Rolloff, KP., Dunn, EZ., Friedman, JE., Barbour, LA., Hernandez, TL., Maclean, PS., Monks, J., McManaman, JL., Rudolph, MC.
- Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue.Breast Cancer Res Treat67,93-109(2001)Stingl, J., Eaves, CJ., Zandieh, I., Emerman, JT.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Breast Cancer Res14,R134(2012)Shehata, M., Teschendorff, A., Sharp, G., Novcic, N., Russell, IA., Avril, S., Prater, M., Eirew, P., Caldas, C., Watson, CJ., Stingl, J.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.
- Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast.Differentiation63,201-13(1998)Stingl, J., Eaves, CJ., Kuusk, U., Emerman, JT.
- Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.Mol Cancer Res17,1556-1570(2019)Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, KD., Storniolo, AM., Nakshatri, H.

CD24(27-59) [plasma membrane] (Homo sapiens)

- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.

KRT19 [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.

ITGA6(24-1130) [plasma membrane] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology.J Mammary Gland Biol Neoplasia25,367-387(2020)Martin Carli, JF., Trahan, GD., Jones, KL., Hirsch, N., Rolloff, KP., Dunn, EZ., Friedman, JE., Barbour, LA., Hernandez, TL., Maclean, PS., Monks, J., McManaman, JL., Rudolph, MC.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Breast Cancer Res14,R134(2012)Shehata, M., Teschendorff, A., Sharp, G., Novcic, N., Russell, IA., Avril, S., Prater, M., Eirew, P., Caldas, C., Watson, CJ., Stingl, J.
- Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.Mol Cancer Res17,1556-1570(2019)Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, KD., Storniolo, AM., Nakshatri, H.

RNA

CD24 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation.Stem Cell Reports2,633-47(2014)Phillips, S., Prat, A., Sedic, M., Proia, T., Wronski, A., Mazumdar, S., Skibinski, A., Shirley, SH., Perou, CM., Gill, G., Gupta, PB., Kuperwasser, C.

KRT18 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.

EPCAM mRNA [cytosol] (Homo sapiens)

- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.

CLDN4 mRNA [cytosol] (Homo sapiens)

- Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology.J Mammary Gland Biol Neoplasia25,367-387(2020)Martin Carli, JF., Trahan, GD., Jones, KL., Hirsch, N., Rolloff, KP., Dunn, EZ., Friedman, JE., Barbour, LA., Hernandez, TL., Maclean, PS., Monks, J., McManaman, JL., Rudolph, MC.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.
- The CD10 enzyme is a key player to identify and regulate human mammary stem cells.Stem Cells28,1081-8(2010)Bachelard-Cascales, E., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., Caron de Fromentel, C., Maguer-Satta, V.

MUC1 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.Breast Cancer Res Treat142,237-55(2013)Prat, A., Karginova, O., Parker, JS., Fan, C., He, X., Bixby, L., Harrell, JC., Roman, E., Adamo, B., Troester, M., Perou, CM.

ESR1 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.Breast Cancer Res12,R21(2010)Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, ML., Vaillant, F., Yagita, H., Lindeman, GJ., Smyth, GK., Visvader, JE.

KRT19 mRNA [cytosol] (Homo sapiens)

- Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Mol Cell Endocrinol361,191-201(2012)Hilton, HN., Graham, JD., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, LI., Mote, PA., Clarke, CL.
- Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis.Commun Biol4,660(2021)Saeki, K., Chang, G., Kanaya, N., Wu, X., Wang, J., Bernal, L., Ha, D., Neuhausen, SL., Chen, S.

Participates

as an output of

Mammary stem cell produces hormone receptor positive luminal progenitor cell (Homo sapiens)

as an input of

Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell (Homo sapiens)