DENV virion binds E ligands

Stable Identifier
R-HSA-9956864
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
extracellular region
ReviewStatus
5/5
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DENV virion binds E ligands
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Dengue virions bind ligands of its envelope (E) protein. Heparin binds with high affinity to the E protein (Yang et al., 2024). Heparin-pretreated hepatocytes of five cell lines showed different susceptibility for dengue virus infection (Lin et al., 2002). Domperidone, an approved dopamine receptor antagonist (Barone, 1999), binds Dengue E protein and reduces Dengue infection in hepatocytes by inhibiting viral RNA replication. All four Dengue serotypes were susceptible (Kaewjiw et al., 2025).
Literature References
PubMed ID Title Journal Year
39680336 Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin

Yang, J, Datta, P, Xia, K, Pomin, VH, Wang, C, Qiao, M, Linhardt, RJ, Dordick, JS, Zhang, F

Glycoconj J 2024
10332535 Domperidone: a peripherally acting dopamine2-receptor antagonist

Barone, JA

Ann Pharmacother 1999
39885306 Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Kaewjiw, N, Thaingtamtanha, T, Mehra, D, Chawnawa, W, Prommool, T, Puttikhunt, C, Songjaeng, A, Kongmanas, K, Avirutnan, P, Luangaram, P, Srisawat, C, Roytrakul, S, Bäurle, SA, Noisakran, S

Sci Rep 2025
12323403 Heparin inhibits dengue-2 virus infection of five human liver cell lines

Lin, YL, Lei, HY, Lin, YS, Yeh, TM, Chen, SH, Liu, HS

Antiviral Res 2002
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-06-15)
Reviewed
Mansur, DS  (2025-10-29)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2025-06-15)
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