Domperidone binds NS1

Stable Identifier
R-HSA-9956857
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
plasma membrane
ReviewStatus
5/5
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Domperidone binds NS1
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Domperidone, an approved dopamine receptor antagonist, binds Dengue NS1 protein and reduces Dengue infection in immortalized hepatocyte-like cells by inhibiting viral RNA replication. All four Dengue serotypes were susceptible (Kaewjiw et al., 2025).
Literature References
PubMed ID Title Journal Year
39885306 Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Kaewjiw, N, Thaingtamtanha, T, Mehra, D, Chawnawa, W, Prommool, T, Puttikhunt, C, Songjaeng, A, Kongmanas, K, Avirutnan, P, Luangaram, P, Srisawat, C, Roytrakul, S, Bäurle, SA, Noisakran, S

Sci Rep 2025
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-06-12)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2025-06-15)
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