Reactome | GBP1 binds actin

GBP1 binds actin

Stable Identifier

R-HSA-9956706

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Guanylate-binding protein 1 (GBP1), an interferon-γ-inducible large GTPase of the dynamin superfamily, directly binds β-actin, interacting most strongly with globular (G)-actin and to a lesser extent with filamentous (F)-actin. This interaction depends on both the GTPase activity and oligomerization capacity of GBP1 and is sufficient to significantly impair actin filament assembly by sequestering G-actin monomers, thereby reducing the pool of polymerization-competent actin (Ostler N et al., 2014). GBP1-induced cytoskeletal remodeling is believed to impair intracellular trafficking of DNA viruses, such as Kaposi’s sarcoma-associated herpesvirus (KSHV) in humans (Zou Z et al., 2017) and pseudorabies virus (PRV) in swine (Zhang X et al., 2023), by disrupting actin-dependent delivery of viral capsids to the nucleus. Further, mass spectrometry analysis of GBP1 interactomes from Toxoplasma gondii–infected human THP-1 cells revealed enhanced interactions with host actin relative to uninfected cells (Fisch D et al., 2023).

Literature References

PubMed ID	Title	Journal	Year
28592529	Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament Zou, Z, Meng, Z, Ma, C, Liang, D, Sun, R, Lan, K	J Virol	2017
24190970	Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor Ostler, N, Britzen-Laurent, N, Liebl, A, Naschberger, E, Lochnit, G, Ostler, M, Forster, F, Kunzelmann, P, Ince, S, Supper, V, Praefcke, GJ, Schubert, DW, Stockinger, H, Herrmann, C, Stürzl, M	Mol Cell Biol	2014