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ZNF598 [cytosol]
Stable Identifier
R-HSA-9948290
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="23"E3 ubiquitin-protein ligase ZNF598 ecNumber evidence="24 25 26 27"2.3.2.27, ZN598_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Ribosome-associated quality control (Homo sapiens)
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Homo sapiens)
ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Homo sapiens)
ZNF598 [cytosol] (Homo sapiens)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Homo sapiens)
ZNF598 [cytosol] (Homo sapiens)
ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Homo sapiens)
ZNF598 [cytosol] (Homo sapiens)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Homo sapiens)
ZNF598 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86UK7 ZNF598
Gene Names
ZNF598
Chain
chain:1-904
Reference Genes
BioGPS Gene:90850 ZNF598
COSMIC - genes:ZNF598 ZNF598
CTD Gene:90850 ZNF598
dbSNP Gene:90850 ZNF598
ENSEMBL:ENSG00000167962 ZNF598
HGNC:28079 ZNF598
KEGG:hsa:90850 ZNF598
Monarch:90850 ZNF598
NCBI Gene:90850 ZNF598
OMIM:617508 ZNF598
UCSC:Q86UK7 ZNF598
Reference Transcript
RefSeq:NM_178167.3 ZNF598
Participates
as an input of
ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Homo sapiens)
as a component of
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Homo sapiens)
Inferred To
znf598 [cytosol]
(Danio rerio)
znf598 [cytosol]
(Xenopus tropicalis)
ZNF598 [cytosol]
(Bos taurus)
ZNF598 [cytosol]
(Canis familiaris)
ZNF598 [cytosol]
(Dictyostelium discoideum)
ZNF598 [cytosol]
(Gallus gallus)
ZNF598 [cytosol]
(Plasmodium falciparum)
ZNF598 [cytosol]
(Schizosaccharomyces pombe)
ZNF598 [cytosol]
(Sus scrofa)
Znf598 [cytosol]
(Mus musculus)
Zfp598 [cytosol]
(Rattus norvegicus)
Dmel\CG11414 [cytosol]
(Drosophila melanogaster)
HEL2 [cytosol]
(Saccharomyces cerevisiae)
znf-598 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_835461.2
OpenTargets
ENSG00000167962
GeneCards
ZNF598
PRO
Q86UK7
Pharos - Targets
Q86UK7
GlyGen
Q86UK7
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:O75420 GGYF1
0.564
2
UniProt:Q8WVZ9 KBTBD7
1
KBTBD7 [cytosol]
(R-HSA-5658415)
0.527
4
UniProt:P63244 RACK1
1
RACK1 [cytosol]
(R-HSA-5626956)
0.527
2
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