NS3 binds PDCD6IP

Stable Identifier
R-HSA-9948266
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS3 binds PDCD6IP
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Programmed cell death 6-interacting protein (PDCD6IP, ALIX) is an accessory protein interacting with components of both ESCRT-I and ESCRT-III complexes of the ESCRT pathway (Martin-Serrano et al., 2003). DENV NS3 binds PDCD6IP, an interaction occurring during late infection or at viral egress that is critical for viral propagation, as its downregulation significantly reduces viral titer. The mechanism of this interaction is unclear (Khadka et al., 2011; Thepparit et al., 2019; reviewed in Rivera-Cuevas & Carruthers, 2023). Increased PDCD6IP expression has been found already in early phases of DENV infection (Pattanakitsakul et al., 2010). Data from Yellow Fever Virus (YFV) point to a role of this reaction in virion egress (Carpp et al., 2011).
Literature References
PubMed ID Title Journal Year
14519844 Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins

Martin-Serrano, J, Yarovoy, A, Perez-Caballero, D, Bieniasz, PD

Proc Natl Acad Sci U S A 2003
21044891 Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles

Carpp, LN, Galler, R, Bonaldo, MC

Microbes Infect 2011
21911577 A physical interaction network of dengue virus and human proteins

Khadka, S, Vangeloff, AD, Zhang, C, Siddavatam, P, Heaton, NS, Wang, L, Sengupta, R, Sahasrabudhe, S, Randall, G, Gribskov, M, Kuhn, RJ, Perera, R, Lacount, DJ

Mol Cell Proteomics 2011
30599162 Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation

Thepparit, C, Khongwichit, S, Ketsuwan, K, Libsittikul, S, Auewarakul, P, Smith, DR

Virus Res 2019
20669987 Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells

Pattanakitsakul, SN, Poungsawai, J, Kanlaya, R, Sinchaikul, S, Chen, ST, Thongboonkerd, V

J Proteome Res 2010
37141275 The multifaceted interactions between pathogens and host ESCRT machinery

Rivera-Cuevas, Y, Carruthers, VB

PLoS Pathog 2023
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-05-18)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2025-05-19)
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