NS4A binds VIM

Stable Identifier
R-HSA-9948108
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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NS4A binds VIM
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Vimentin interacts with the N-terminal cytosolic portion of the NS4A protein from DENV-2 (NGC strain) in replication complexes (RCs) in the endoplasmic reticulum of human Huh-7 cells (Teo & Chu, 2014; reviewed in Ramos et al., 2020). DENV-2 infection is associated with vimentin reorganization and its phosphorylation by calcium calmodulin-dependent protein kinase II (CaMKII); this reorganization is important for maintaining and supporting the DENV RCs (Teo & Chu, 2014).
Literature References
PubMed ID Title Journal Year
24284321 Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein

Teo, CS, Chu, JJ

J Virol 2014
32630064 Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections

Ramos, I, Stamatakis, K, Oeste, CL, Pérez-Sala, D

Int J Mol Sci 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-05-15)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2025-05-16)
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