Reactome | SPAM1 randomly cleaves HA

SPAM1 randomly cleaves HA

Stable Identifier

R-HSA-9941055

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Hyaluronidase SPAM1 (PH-20) randomly hydrolyzes (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate (HA) (Gmachl et al., 1993; reviewed in Cherr et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
8282124	The human sperm protein PH-20 has hyaluronidase activity Gmachl, M, Sagan, S, Ketter, S, Kreil, G	FEBS Lett	1993
11731269	The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling Cherr, GN, Yudin, AI, Overstreet, JW	Matrix Biol	2001