PXYLP1 dephosphorylates Xyl moiety

Stable Identifier
R-HSA-9940993
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen
ReviewStatus
5/5
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PXYLP1 dephosphorylates Xyl moiety
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2-Phosphoxylose phosphatase 1 (PXYLP1) dephosphorylates the xylose (Xyl) moiety of the GAG linker glycan chain of proteoglycans, making the chain available for the biosynthesis of heparan/chondoitin/dermatan (Koike et al., 2014; reviewed in Nowicka & Gręda, 2019).
Literature References
PubMed ID Title Journal Year
24425863 Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans

Koike, T, Izumikawa, T, Sato, B, Kitagawa, H

J Biol Chem 2014
31885391 Chondroitin sulfate metabolism in the brain

Nowicka, D, Gręda, A

Acta Neurobiol Exp (Wars) 2019
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
positive regulation of proteoglycan biosynthetic process (1902730)
Catalyst Activity

phosphatase activity of PXYLP1 [Golgi membrane]

Physical Entity
PXYLP1 [Golgi membrane] (Homo sapiens)
Activity
phosphatase activity (GO:0016791)
Orthologous Events
PXYLP1 dephosphorylates Xyl moiety (Bos taurus)
PXYLP1 dephosphorylates Xyl moiety (Canis familiaris)
PXYLP1 dephosphorylates Xyl moiety (Danio rerio)
PXYLP1 dephosphorylates Xyl moiety (Drosophila melanogaster)
PXYLP1 dephosphorylates Xyl moiety (Gallus gallus)
PXYLP1 dephosphorylates Xyl moiety (Mus musculus)
PXYLP1 dephosphorylates Xyl moiety (Rattus norvegicus)
PXYLP1 dephosphorylates Xyl moiety (Sus scrofa)
PXYLP1 dephosphorylates Xyl moiety (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2025-02-15)
Reviewed
D'Eustachio, P  (2025-05-15)
Created
Stephan, R  (2025-03-07)
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