Reactome | CHST10 sulfates matriglycan chain

CHST10 sulfates matriglycan chain

Stable Identifier

R-HSA-9940718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen

ReviewStatus

5/5

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Carbohydrate sulfotransferase 10 (CHST10, HNK-1) transfers sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of the terminal glucuronic acid (GlcA) moiety of growing matriglycan chains on alpha-dystroglycan. This modfication prevents further polymerization by LARGE glycosyltransferases (Sheikh et al., 2020; reviewed in Katz & Diskin).

Literature References

PubMed ID	Title	Journal	Year
38516183	The underlying mechanisms of arenaviral entry through matriglycan Katz, M, Diskin, R	Front Mol Biosci	2024
32149355	HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan Sheikh, MO, Venzke, D, Anderson, ME, Yoshida-Moriguchi, T, Glushka, JN, Nairn, AV, Galizzi, M, Moremen, KW, Campbell, KP, Wells, L	Glycobiology	2020