Interferon regulatory factor-1 (IRF-1) is a positive transcription factor for genes involved in immune response, cell growth regulation and apoptosis in mammalian cells. Many agents such as viruses, interferon (IFN), double-stranded RNA (dsRNA), and proinflammatory cytokines induce IRF-1 transcription. IRF-1 transcriptionally activates many IRF-1-regulated genes during normal physiological and pathological conditions, including interferon-beta and alpha (Escalante et al. 1998, Harada et al. 1990), iNOS, COX-2, VCAM-1, IL-12, IL-15, CIITA, Caspase-1 and Caspase-7 (Upreti & Rath 2005).