IRF1 binds the promoters of Interferon alpha and beta

Stable Identifier
Reaction [transition]
Homo sapiens
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Interferon regulatory factor-1 (IRF-1) is a positive transcription factor for genes involved in immune response, cell growth regulation and apoptosis in mammalian cells. Many agents such as viruses, interferon (IFN), double-stranded RNA (dsRNA), and proinflammatory cytokines induce IRF-1 transcription. IRF-1 transcriptionally activates many IRF-1-regulated genes during normal physiological and pathological conditions, including interferon-beta and alpha (Escalante et al. 1998, Harada et al. 1990), iNOS, COX-2, VCAM-1, IL-12, IL-15, CIITA, Caspase-1 and Caspase-7 (Upreti & Rath 2005).

Literature References
PubMed ID Title Journal Year
9422515 Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

Thanos, D, Escalante, CR, Yie, J, Aggarwal, AK

Nature 1998
3409321 Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements

Harada, H, Taniguchi, T, Miyata, T, Fujita, T, Kimura, Y, Miyamoto, M, Maruyama, M, Sudo, Y

Cell 1988
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