Reactome | FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

Stable Identifier

R-HSA-9936451

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

FXI:kininogen binds GPIb:IX:V

ReviewStatus

5/5

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FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

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Coagulation factor XI circulates in plasma predominantly as a non-covalent complex with high molecular weight kininogen (HK), encoded by the KNG1 gene (depicted here as KNG1(19-644)). HK anchors FXI to surfaces, facilitating its activation by factor FXIIa (Renné T et al., 2002; Li C et al., 2023; Mohammed BM et al., 2024). Both FXI and HK were shown to interact with the platelet glycoprotein GPIb:IX:V complex in a Zn²⁺-dependent manner (Joseph K et al., 1999; Chavakis T et al., 2003; Baglia FA et al., 2004; reviewed by Pathak M et al., 2018). Since the majority of FXI circulates bound to HK, it may also localize to endothelial cell membranes via HK interactions with cytokeratin 1 (CK1), urokinase plasminogen activator receptor (uPAR), and gC1qR (Mahdi F et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12952972	High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib Chavakis, T, Santoso, S, Clemetson, KJ, Sachs, UJ, Isordia-Salas, I, Pixley, RA, Nawroth, PP, Colman, RW, Preissner, KT	J Biol Chem	2003
10501658	Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen Joseph, K, Nakazawa, Y, Bahou, WF, Ghebrehiwet, B, Kaplan, AP	Mol Med	1999
15317813	Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI Baglia, FA, Gailani, D, Lopez, JA, Walsh, PN	J Biol Chem	2004