PD-1 binds PD-L1,PD-L2

Stable Identifier
R-HSA-9936162
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PD-1 binds PD-L1,PD-L2
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Programmed cell death protein 1 (PD-1, also known as PDCD1) binds to its ligands, PD-L1 (B7-H1, also known as CD274) and PD-L2 (B7-DC, also known as PDCD1LG2 or CD273), to exert its inhibitory effects on T cell activation and immune response. PD-1 displays different affinities for these ligands, with the PD-1:PD-L2 interaction exhibiting a 2- to 6-fold higher affinity compared to the PD-1:PD-L1 interaction, along with distinct association and dissociation kinetics. This binding primarily occurs at the immune synapse, where PD-1 engagement with its ligands leads to the recruitment of phosphatases SHP-1 (PTPN6) and SHP-2 (PTPN11). These phosphatases dephosphorylate key signaling molecules in the T cell receptor (TCR) pathway, resulting in reduced T cell proliferation, cytokine production, and overall immune response. The interaction of PD-1 with its ligands is crucial for maintaining immune tolerance and preventing autoimmunity, as well as contributing to immune evasion in cancer (Youngnak et al. 2003, Pentcheva-Hoang et al. 2007).
Literature References
PubMed ID Title Journal Year
12893276 Differential binding properties of B7-H1 and B7-DC to programmed death-1

Youngnak, P, Kozono, Y, Kozono, H, Iwai, H, Otsuki, N, Jin, H, Omura, K, Yagita, H, Pardoll, DM, Chen, L, Azuma, M

Biochem Biophys Res Commun 2003
Participants
Input
Output
Entity On Other Cell
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as an event of
This event is regulated
Negatively by
Regulator
PDCD1:PDCD1 inhibitors [plasma membrane] (Homo sapiens)
Orthologous Events
PD-1 binds PD-L1,PD-L2 (Bos taurus)
PD-1 binds PD-L1,PD-L2 (Canis familiaris)
PD-1 binds PD-L1,PD-L2 (Gallus gallus)
PD-1 binds PD-L1,PD-L2 (Mus musculus)
PD-1 binds PD-L1,PD-L2 (Rattus norvegicus)
PD-1 binds PD-L1,PD-L2 (Sus scrofa)
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2025-01-21)
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