DXO hydrolyzes uncapped RNA

Stable Identifier
R-HSA-9935265
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DXO hydrolyzes uncapped RNA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DXO has distributive 5'-3' exoribonucleolytic activity on substrates possessing a 5' phosphate or a 5' hydroxyl group (inferred from mouse homologs). DXO initially releases a dinucleotide product with a 5' hydroxyl RNA, then subsequently releases single nucleotides (inferred from the mouse homolog).
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Catalyst Activity

5'-3' RNA exonuclease activity of DXO:Mg2+ [nucleoplasm]

Physical Entity
DXO:Mg2+ [nucleoplasm] (Homo sapiens)
Activity
5'-3' RNA exonuclease activity (GO:0004534)
Inferred From
Dxo hydrolyzes uncapped RNA (Mus musculus)
Authored
May, B  (2025-01-12)
Reviewed
Anonymous, R  (2025-02-17)
Tong, L  (2025-10-23)
Created
May, B  (2025-01-14)
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