Proteolysis of K48polyUb-K,p-S-PER1,2,3

Stable Identifier
R-HSA-9934893
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteolysis of K48polyUb-K,p-S-PER1,2,3
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The proteasome degrades K48-polyubiquitinylated, phosphorylated PER1 and, by inference, K48-polyubiquitinylated PER2 and PER3 (Shirogane et al. 2005). Ubiquitinylation and degradation of PER1 is dependent on its phosphorylation by CSNK1E (Shirogane et al. 2005), and, by inference, CSNK1D.
Literature References
PubMed ID Title Journal Year
15917222 SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

Shirogane, T, Jin, J, Ang, XL, Harper, JW

J Biol Chem 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Bos taurus)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Canis familiaris)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Danio rerio)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Drosophila melanogaster)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Gallus gallus)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Mus musculus)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Rattus norvegicus)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Sus scrofa)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Xenopus tropicalis)
Authored
May, B  (2025-01-11)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2025-01-12)
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