Reactome | TMTC3 [endoplasmic reticulum membrane]

TMTC3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9933102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein O-mannosyl-transferase TMTC3, Transmembrane O-mannosyltransferase targeting cadherins 3

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 is O-manosylated (Homo sapiens)
        
        TMTC3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6ZXV5 TMTC3

Gene Names

TMTC3

Chain

chain:1-915

Reference Genes

BioGPS Gene:160418 TMTC3

COSMIC - genes:TMTC3 TMTC3

CTD Gene:160418 TMTC3

dbSNP Gene:160418 TMTC3

ENSEMBL:ENSG00000139324 TMTC3

HGNC:26899 TMTC3

KEGG:hsa:160418 TMTC3

Monarch:160418 TMTC3

NCBI Gene:160418 TMTC3

OMIM:617218 TMTC3

UCSC:Q6ZXV5 TMTC3

Reference Transcript

RefSeq:NM_181783.4 TMTC3

Other Identifiers

11724915_at

11724916_at

11724917_at

11724918_a_at

1560017_PM_at

1560017_at

160418

16754935

226600_PM_at

226600_at

226604_PM_at

226604_at

3425054

3425135

3425136

3425137

3425138

3425139

3425141

3425142

3425143

3425144

3425145

3425146

3425147

3425148

3425149

3425150

3425151

3425152

3425153

3425154

3425155

3425156

51908_at

64206_s_at

64207_r_at

64208_r_at

69414_at

7957478

A_14_P120857

A_14_P134281

A_23_P48264

A_24_P141804

A_24_P918266

A_24_P944222

GE87643

GO:0000030

GO:0003824

GO:0004169

GO:0005515

GO:0005783

GO:0006486

GO:0016020

GO:0016740

GO:0034976

GO:0035269

GO:0060255

GO:0140096

GO:1901800

HMNXSV003025146

Hs.29643.0.A1_3p_at

Hs.29643.0.A2_3p_at

Hs2.381362.1.S1_3p_at

ILMN_1732566

ILMN_2119555

PH_hs_0022961

TC12000694.hg

Inferred To

Tmtc3 [endoplasmic reticulum membrane] (Mus musculus)

Tmtc3 [endoplasmic reticulum membrane] (Rattus norvegicus)

tmtc3 [endoplasmic reticulum membrane] (Danio rerio)

tmtc3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

TMTC3 [endoplasmic reticulum membrane] (Bos taurus)

TMTC3 [endoplasmic reticulum membrane] (Canis familiaris)

TMTC3 [endoplasmic reticulum membrane] (Gallus gallus)

TMTC3 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_861448.2

ENSEMBL

ENST00000266712, ENSG00000139324, ENSP00000266712

OpenTargets

ENSG00000139324

GeneCards

TMTC3

HPA

ENSG00000139324-TMTC3

PRO

Q6ZXV5

Pharos - Targets

Q6ZXV5

GlyGen

Q6ZXV5

Orphanet

TMTC3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75553 DAB1	2	DAB1 [cytosol] (R-HSA-8855236) p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227)	0.556	3
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:Q6PIU2 NCEH1	1	NCEH1 [endoplasmic reticulum membrane] (R-HSA-6813685)	0.527	2

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